Effect Of Geraniol On Brain Cholesterol, Vitamin A And E Levels In The Hydrogen Peroxide-Treated Rats

AHMET ORHAN GÖRGÜLÜ, AHMET ÖZKAYA, ÖKKEŞ YILMAZ, ZAFER ŞAHİN

  • Yıl : 2018
  • Cilt : 34
  • Sayı : 1
  •  Sayfa : 18-22
Aim: Geraniol, a monoterpene, is a plant-derived natural antioxidant. Hydrogen peroxide (H2O2) is a member of reactive oxygen species (ROS). The objective of this study is to de-termine the effect of geraniol on brain cholesterol and lipophilic vitamins such as vitamin A (retinol) and vitamin E (alpha (α)- tocopherol and α-tocopherol acetate) in H2O2-administrated male rats. Materials and Methods: Adult male Wistar rats were randomly divided into four groups (n=7). Geraniol (50 mg/kg) and H2O2 (16 mg/kg) were administered by an intraperitoneal injection for 30 days with a 1-day interval. Brain samples were homogenized and cholesterol, α-tocopherol, α-tocopherol acetate, and retinol levels analyzed from lipid extracts by HPLC. Results: Brain cholesterol level was found to be significantly higher in the H2O2 group than the control group. Brain α-tocopherol acetate levels were found to be significantly higher in the H2O2 and the geraniol+H2O2 groups than the control group. There was no difference in retinol levels between any groups. Conclusion: In conclusion, our results indicate that brain cholesterol and α-tocopherol acetate levels are affected by H2O2-induced oxidative stress. Moreover, we suggest that geraniol has the potential to reduce the effect of H2O2 in male rats.
Atıf yapmak için : Şahin Z, Özkaya A, Yılmaz Ö, Görgülü AO. Effect of Geraniol on Brain Cholesterol, Vitamin A and E Levels in The Hydrogen Peroxide-Treated Rats. Selcuk Med J 2018;34(1): 18-22
Açıklama : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler.
Effect Of Geraniol On Brain Cholesterol, Vitamin A And E Levels In The Hydrogen Peroxide-Treated Rats
, Vol. 34 (1)
Geliş Tarihi : 19.05.2017, Kabul Tarihi : 19.05.2017, Yayın Tarihi : 13.08.2018
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;