IS VITAMIN D ASSOCIATED WITH THE PRESENCE, TYPE AND SEVERITY OF MIGRAINE?

Introduction: Migraine is a neurovascular disease that is common worldwide. In a few studies, a relationship was found between vitamin D levels and headache severity and types. In this study, we primarily investigated whether there was a difference in vitamin D levels between migraine patients and healthy controls, and secondarily, whether there was a relationship between types and severity of migraine and vitamin D levels.

Patients and Methods: This case-control study was carried out between January 2021 - July 2022 at ***** University ***** Faculty of Medicine, Department of Neurology. 204 patients over the age of 18 who were diagnosed with migraine and 204 healthy volunteers without headache were included in our study. The diagnosis of migraine was made by a neurologist according to the International Headache Society 3 criteria.

Results: The mean vitamin D level was 15.30±9.93 ng/dl in the migraine group and 14.62±7.93 ng/dl in the control group. There was no statistically significant difference between the two groups (p=0.976). There was no difference between migraine patients and the control group in terms of vitamin D deficiency and insufficiency (p=0.365).

Conclusion: According to the results of our study, we did not find any difference in vitamin D levels between migraine patients and the normal population. There was no statistical difference in vitamin D levels among migraine subtypes. In addition, no relationship was found between severity and frequency of migraine attacks and vitamin D levels. According to the results of our study, the high prevalence of vitamin D deficiency appears to be a common problem in both migraine patients and the healthy population, and randomized clinical studies with large sample numbers are needed on this subject.