Evaluation Of Short Term Effects Of Hyperbaric Oxygen And Enoxaparin Treatments In Avascular Necrosis Of Femoral Head

ABDULLAH ARSLAN, FATİH DİKİCİ, SEVİM PURİSA, SALİH AYDIN, VAKUR OLGAÇ

  • Yıl : 2019
  • Cilt : 35
  • Sayı : 2
  •  Sayfa : 77-84

ABSTRACT

Aim: Avascular necrosis of the femoral head (AVN) is the necrosis of the bone and the bone marrow resulting from the injury or the occlusion of the blood supplying vessels of the femoral head. Specially it is seen in mostly young and middle aged individuals and requiring mostly surgical procedures. Despite all advances in the surgical procedures, still a high rate of the hip prosthesis is a requirement in the treatment. Hyperbaric Oxygen Therapy (HBOT) alone or in combination with surgery is reported to be effective in some clinical AVN cases. HBOT is also a treatment method which is used in ischemic diseases resulting from vascular injuries or occlusions. Enoxaparin is an antagonist of factor Xa which is found in the coagulation system. Beside its anticoagulant effect it has been shown that it has an osteopenic effect, inhibits osteoblast maturation and increases osteoclast activity in the bone.

Material and Methods: In this study effects of enoxaparin and HBOT were investigated in the treatment of experimentally formed AVN of the femoral heads of the rats. For this purpose, avascular necrosis model was applied to the left femoral heads of 64 rats and the results of the treatments alone and together were investigated.

Results: In this study results have shown that an increase in the new bone formation, and remodelisation with less changes in the cartilage tissue than in the controls. An increase in the necrotic tissue clearing rate observed in the HBOT applied groups. The best results were achieved with the HBOT and enoxaparin combined applications.

Conclusion: In this study HBOT alone, enoxaparin alone or combination of these two treatments have a positive effect in the experimental femoral head AVN and supporting the clinical studies in the femoral head AVN.

Keywords: Hyperbaric oxygen therapy, avascular necrosis, enoxaparin

Atıf yapmak için : Arslan A, Dikici F, Purisa S, Olgac NV, Aydin S. Evaluation of Short Term Effects of Hyperbaric Oxygen and Enoxaparin Treatments in Avascular Necrosis of Femoral Head. Selcuk Med J 2019;35(2): 77-84
Açıklama : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler.
Evaluation Of Short Term Effects Of Hyperbaric Oxygen And Enoxaparin Treatments In Avascular Necrosis Of Femoral Head
, Vol. 35 (2)
Geliş Tarihi : 09.03.2019, Kabul Tarihi : 09.03.2019, Yayın Tarihi : 27.03.2019
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;