Direkt Oral Antikoagülan İlaçların Platelet İndekslerine Etkileri Ve Bunun Kanama Olaylarıyla İlişkisi

The Effect of Direct Oral Anticoagulant Drugs

Fatih Aydın,Özge Turgay Yıldırım,Ercan Akşit,Evrin Dağtekin,Ayşe Hüseyinoğlu Aydın

Özeti

Aim: Atrial fibrillation is a common disorder and is an important cause of thromboembolic events. Recently, direct oral anticoagulant drugs (DOACs) are being used to reduce the frequency of thromboembolic events among these patients. DOACs have several advantages over oral vitamin K antagonists, such as fixed dosage and fewer side effects. However, since the drugs and their affects cannot be monitored directly, difficulties are encountered in assessing drug efficacy and side effects. For this purpose, platelet indices and their relationship with DOACs may be utilized for the prediction of thromboembolic and hemorrhagic events.

Patients and Methods: 301 patients with atrial fibrillation who were using DOACs were included in the study. Platelet indices such as platelet count, platelet distribution volume, plateletcrit, platelet-large cell ratio were evaluated at the first and sixth months. The effect of DOACs on these indices and relationships with bleeding events were investigated.

Results: All groups were similar in regard to baseline platelet indices, except for lower P-LCR value among recipients of rivaroxaban. When post-treatment results were compared, all groups were found to have similar values in all parameters. However, time-bound comparisons revealed that apixaban and dabigatran significantly reduced P-LCR value after 6 months of use.

Conclusion: This study showed that apixaban, rivoraxaban and dabigatran had no effect on platelet count, MPV, PDW, PCT values in whole blood count of patients with non-valvular AF. All characteristics of those with and without hemorrhagic events were also similar of patients with non-valvular AF.

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Yazışma Adresi : Fatih Aydın, Eskişehir Şehir Hastanesi Kardiyoloji
Eposta : drfatihaydin@hotmail.com
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Açıklama : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Direkt Oral Antikoagülan İlaçların Platelet İndekslerine Etkileri Ve Bunun Kanama Olaylarıyla İlişkisi, Araştırma makalesi,
Geliş Tarihi : 05.05.2020, Kabul Tarihi : 05.05.2020
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ISSN:1017-6616 ;
E-ISSN:2149-8059 ;
İndeksleme
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