Objective: Nitric oxide (NO) and free oxygen radicals have been implicated in the pathogenesis of intestinal circulatory dysfunction in sepsis. The aim of this study is to investigate the effects of pentoxyfillin, L-arginin and Aminoguanidine on plasma malondialdehide (MDA) and nitric oxide (NO) levels, and to determine the relations between MDA and NO levels on intestine pathology. Methods: 60 Wistar Albino rats were used in this study. The rats were divided into 6 groups, each containing 10 subjects. Sepsis was induced by cecal ligation and puncture (CLP) method. Group I: Sham group, Group II: CLP (sepsis), Group III: CLP + 10 mg/kg L-arginin admiministration, Group IV: CLP + 15 mg/kg Aminoguanidine administration, Group V: CLP + L-arginin + Aminoguanidine (as groups III and IV) Group VI: CLP + 15 mg/kg/day pentoxyfillin. Blood samples were taken fort he determination of NO, MDA, leukocyte counts, a segment of ileum tissue sample was obtained for determination of tissue damage. Results: Leukocyte count increased in CLP induced groups significantly. While NO levels were significantly higher in sepsis and L-arginin groups the levels in Aminoguanidine and Aminoguanidine + L-arginin groups were similar to Sham group. Intestine tissue damage in sepsis and L-arginin groups were more severe than the other groups. MDA levels in CLP induced groups were found to be higher than the sham group. Conclusion: Aminoguanidine and Pentoxifillin may be added to treatment protocols in sepsis in order to prevent intestinal tissue damage and dysfunction both of which (at least partially) caused by elevated NO levels.