Antifungal drug resistance in candida albicans

DUYGU FINDIK, EMİNE İNCİ TUNCER, ONUR URAL, UĞUR ARSLAN

  • Year : 2001
  • Vol : 17
  • Issue : 4
  •  Page : 217-220
İn this study the antifungal susceptibility patterns of 63 clinical isolates of Candida albicans isolated from from hospitalized patiens vvere studied against amphotericin B, ketoconazole fluconazole and itraconazole using the Epsilometer test (E-test). Most of the isolates vvere isolated from urine samples (76.1%). The MIC ranges determined at 24 h incubation for amphotericin B, ketoconazole fluconazole and itraconazole vvere: <0.002-0.38. 0.004->32, 0.25->256, 0.008->32 respectively. The MIC50 and MIC90 (mg/l) for each antifungal vvere; amphotericin B 0.032, 0.125, ketoconazole 0.38, 4, fluconazole 2, 64 and itraconazole 0.094, 3. Ali strains vvere susceptible to amphotericin B, the resistance rates vvere 19.2% for fluconazole and 17.8% for itraconazole. Five İsolates shovved >32mg/l MIC values for ketoconazole. The results indicate that there is resistance against antifungal agents and this increases the importance of antifungal susceptibility tests.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Antifungal drug resistance in candida albicans
, Vol. 17 (4)
Received : 27.04.2001, Accepted : 27.04.2001, Published Online : 02.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;