Alport syndrome

The recent developments involving the molecular basis, diagnosis and treatment of Alport's syndrome was reviewed. The determination of the nature of type IV collağen and localisation of its genes have provided new insights in the understanding of the different sign and symptoms of Alport's syndorme and helped to reach new approaches in diagnosis and treatment. Immunohistochemical examinations may help to distinguish the X linked and autosomal forms of Alport's syndrome. The genomic investigations may be reçuired in suspected cases. İn this disease with no effective treatment the gene therapy is promising.