Comparison Of The Effects Of Mannitol Or Hypertonic Saline Solutions In Head Trauma Model

We aimed to compare the effects of 20 % mannitol, 3 % or 7 % hypertonic saline on hemodynamic parameters, intracranial pressure and electroencephalography in experimental head trauma. Bilateral craniotomy were carried out in the parietal region and standart head trauma was applied for all rabbits. The rabbits were randomly divided into four groups. In group I rabbits were only observed. In group II: 20 % mannitol, in group III: 3 % hypertonic saline and in group IV: 7 % hypertonic saline was administered intravenously to achieve similar osmolar load. Electroencephalography, mean arterial pressure, heart rate, intracranial pressure were recorded before trauma and 5 and 60 minutes after trauma. Increased intracranial pressure was significantly decreased by mannitol, 3 % and 7 % hypertonic saline solutions at the end of study (p0.05). The mean arterial pressure and heart rates increased after trauma in all groups (p