Comparison of the Effects of Nasal Flunitrazeparn and Rectal Midazolam Premedications on the Preoperative Sedation and Induction in Children.

We evaluated the effects of nasal administered flunitrazepam and rectal midazolam on preoperative anxiety in children of ages 1 to 12. 0.03 mg.kg-1 nasal fhtnitrazepam for group I (NF) and 0.45 mg.kg"/ rectal midazolam (RM) was given to group 30 min before the operation. The Subjective Numerical Anxiety - Sedation Scores (SNAS) were recorded before premedication and induction. Cardiovascular variables and respiratory complications were recorded during inhalational induction with isoflurane. Complications were more frequent in the NF group (% 58.33), although the SNAS scores were similar before premedication in both groups, before induction the anxiety scores in the NI,' group and the sedation scores in RM group were increased. A rise in heart rate (HR) was recorded in both of the groups (p<0.05), In the NF group a significant increase at the fifth minute (p<0.05) and a very significant increase during the first minute (p<0.001) occured in the systolic blood pressures (SBP), in the RM group a significant rise in diastolic blood pressure (DBP) was recorded during the first minute. As a result, we have concluded that while nasal)) administered flunitrazepam is not a favorable premedication agent. rectal midazolam is effective and safe in children for premedication.