DOES SERTRALINE AFFECT CONTRACTION IN ENDOTHELIUM-DAMAGED AORTA

Z IŞIK SOLAK GÖRMÜŞ, Cahit Burkay Eker, HATİCE SOLAK, RAVİYE ÖZEN KOCA, FAİK ÖZDENGÜL

  • Z IŞIK SOLAK GÖRMÜŞ: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Cahit Burkay Eker: Beykoz Üniversitesi Sağlık Meslek Yüksekokulu
  • RAVİYE ÖZEN KOCA: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • FAİK ÖZDENGÜL: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Year : 2024
  • Vol : 40
  • Issue : 1
  •  Page : 8-15
ABSTRACT
Aim: Selective Serotonin Reuptake Inhibitor (SSRI) group antidepressants are frequently used in heart patients. In the study, we aimed to investigate the effects of sertraline (SE) on aortic contraction on healthy/damaged rat aorta. 
Materials and Methods: Wistar albino rats (24) were divided into group1-aorta-intact endothelium and group2-aorta-damaged endothelium. The isolated aortic tissues were placed in organ baths. Changes in the isometric tension of the aortic rings were recorded. Contractions were recorded in both groups after the application of phenylephrine (PE 10-6M). Afterwards, cumulative sertraline (SE 50 mg) (10-9-10-4M) was given to group 1. In Group 2, to control aortic endothelial damage, acetylcholine (10-6M) was applied and the tissues were washed for an hour, the second dose of PE was given, then SE was given cumulatively (10-9-10-4M), and contractions were recorded.
Results: After cumulative SE (10-9-10-4M) was given to Group 1, a significant inhibition in spontaneous contractions was detected in the first three sertraline doses (10-9,10-8,10-7)(p<0.05), and in the remaining sertraline doses contraction inhibition continued. When comparing SE 10-6,-5,-4 and 10-9,-8,-7 doses, there was inhibition of contractions (p<0.005). In group2, the inhibition of second PE contractions continued after sertraline doses, but the inhibition was observed less than in group1 (p<0.05).
Conclusion: SE inhibited PE-induced smooth muscle contraction in rat isolated aorta. PE-induced smooth muscle contractions were inhibited more slowly in the endothelium-damaged aorta. It is thought that NO release and NO-dependent vasodilation in the aorta decrease as a result of damage. A clearer understanding of the effects of sertraline on the cardiovascular system will be possible with further research.
Keywords: Aorta, endothelium, sertraline, contraction, vasorelaxation
Cite this Article As : Solak Gormus ZI, Eker CB, Solak H, Ozen Koca R, Ozdengul F. Does Sertraline Affect Contraction in Endothelium Damaged Aorta? Selcuk Med J 2024;40(1): 8-15

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2024, Vol. 40 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

References

  1. 1. David LH, Samia RT, Peter J. Depression and cardiovascular disease: a clinical review. Eur Heart J 2014;35(21):1365-72.
  2. 2. Wynn A. Unwarranted emotional distress in men with ischemic heart disease (IHD). Med J Aust 1967;4;2(19):847-51.
  3. 3. Cay EL, Vetter N, Philip NE, Dugard P. Psychological status during recovery from an acute heart attack. J Psychosom Res 1972;16:425–35.
  4. 4. Thombs BD, de Jonge P, Coyne JC. Depression screening and patient outcomes in cardiovascular care: a systematic review. JAMA 2008;12;300(18):2161–71.
  5. 5. Meijer A, Conradi HJ, Bos EH. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research. Gen hosp Psychiatry 2011;33(3):203
  6. 6. Thomas SJ, Shin M, McInnis MG. Combination therapy with monoamine oxidase inhibitors and other antidepressants or stimulants: strategies for the management of treatment-resistant depression. Pharmacotherapy 2015;35(4):433–49.
  7. 7. Anderson IM. Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability. J Affect Disord 2000;58(1):19-36.
  8. 8. Chu A, Wadhwa R. Selective Serotonin Reuptake Inhibitors. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
  9. 9. Hoffman RS. Off-Label Uses for Selective Serotonin Reuptake Inhibitors. Am Fam Physician 2005;1;71(1):4346
  10. 10. Cipriani A, La Ferla T, Furukawa TA. Sertraline versus other antidepressive agents for depression. Cochrane Database Syst Rev 2010;14;(4):CD006117
  11. 11. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;27;288(5789):373-76.
  12. 12. Pueyo ME, Arnal JF, Rami J. Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells. Am J Physiol 1998;274(1):C214-20.
  13. 14. Linder L, Kioski W, Buhler FR. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation 1990;81(6)1762-7.
  14. 15. Stauffer BL, Westby CM, DeSouza CA. Endothelin-1, aging and hypertension. Curr Opin Cardiol 2008;23(4): 350-5.
  15. 16. Vanhoutte PM. The endothelium-Modulator of vascular smooth muscle tone. N Engl J Med
  16. 1988;25;319(8):512-3.
  17. 17. Tousoulis D, Kampoli AM, Tentolouris C. The role of nitric oxide on endothelial function. Curr Vasc Pharmacol. 2012;10(1):4–18
  18. 18. Nurullahoğlu-Atalık KE, Kutlu S, Solak H. Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging. Physiol Int 2017;104(3):226–34.
  19. 19. Ostuzzi G, Matcham F, Dauchy S. Antidepressants for the treatment of depression in people with cancer. Cochrane Database Syst Rev 2018;23;4(4):CD011006.
  20. 20. Nezafati MH, Vojdanparast M, Nezafati P. Antidepressants and cardiovascular adverse events: A narrative review. ARYA Atheroscler 2015;11(5):295–304.
  21. 21. Fioranelli M, Bottaccioli AG, Bottaccioli F. Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based. Front Immunol 2018;6;9:2031.
  22. 22. Edinoff AN, Akuly HA, Hanna TA. Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review. Neurol Int 2021;13(3):387–401.
  23. 23. Maes M., Song C., Lin A.H., Bonaccorso S., Kenis G., De Jongh R., Bosmans E., & Scharpé S. Negative immunoregulatory effects of antidepressants: Inhibition of interferon-gamma and stimulation of interleukin-10 secretion. Neuropsychopharmacology. 1999;20:370–379.
  24. 24. Ouyang W, Rutz S, Crellin NK. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 2011;29:71–109.
  25. 25. Lekakis J, Ikonomidis I, Papoutsi Z. Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules. Int J Cardiol 2010;4;139(2):150–8.
  26. 26. Vila JM, Medina P, Segarra G. Relaxant effects of antidepressants on human isolated mesenteric arteries. Br J Clin Pharmacol 1999;48(2):223–9.
  27. 27. Işık B, Özen Koca R, Solak Görmüş, ZI. Vasoactive effects of fluoxetine in rat thoracic aorta smooth muscle. Cukurova Medical Journal, 2022;47(2):729-37.
  28. 28. Melle Van JP, Buikema H, van den Berg MP. Sertraline causes strong coronary vasodilation: Possible relevance for cardioprotection by selective serotonin reuptake inhibitors. Cardiovasc Drugs Ther 2004;18(6):441.
  29. 29. Ungvari Z, Pacher P, Kecskeméti V. Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca2+ channel opener. Stroke 1999;30(9):1949-54.
  30. 30. Wu S, Zhou Y, Xuan Z. Repeated use of SSRIs potentially associated with an increase on serum CK and CKMB in patients with major depressive disorder: a retrospective study. Sci Rep 2021;28;11(1):13365.