Dose-Dependent Effects Of Octreotide On Oxidant-Antioxidant Status And Lung Histopathology During Experimental Sepsis

ABDÜSSELAM SEYDANOĞLU, MEHMET GÜL, SAMİ ERDEM, HARUN PERU, MURAT AYAN, HATİCE TOY, METİN BİRCAN, ABDULLAH SADIK GİRİŞGİN

  • ABDÜSSELAM SEYDANOĞLU: GAZİOSMANPAŞA ÜNİVERSİTESİ
  • MEHMET GÜL: SELÇUK ÜNİVERSİTESİ
  • SAMİ ERDEM: SELÇUK ÜNİVERSİTESİ
  • HARUN PERU: SELÇUK ÜNİVERSİTESİ TIP FAKÜLTESİ
  • MURAT AYAN: GAZİ OSMAN PAŞA ÜNİV.
  • HATİCE TOY: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • METİN BİRCAN: ADNAN MENDERS ÜNİVERSİTESİ
  • ABDULLAH SADIK GİRİŞGİN: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Year : 2010
  • Vol : 26
  • Issue : 3
  •  Page : 90-94
The aim of the study was to investigate Octreotide (OCT), a synthetic somatostatin analogue, effects on oxidant -antioxidant status and lung histopathology in experimental sepsis. Fourty Sprague-Dawley rats were randomly divided into four groups. Group SHAM underwent only laparotomy. In Group SEPSİS, OCT-50 and OCT-100 were performed sepsis by Cecal Ligation and Perforation (CLP) technique. Group OCT-50 and group OCT-100 received subcutanously (sc) OCT 50 μg/kg and 100 μg/kg respectively after CLP. Group SHAM and group SEPSİS received in same time, route and dose SF. All rats after operation at 24 h. were sacrificed and collected blood and lung tissue samples. Erythrocyte GSH, plasma MDA and lung histopathology were assessed. In group SEPSİS , while MDA levels and lung damage scors increased in sepsis periods, GSH decreased when compared with group SHAM (p

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2010, Vol. 26 (3)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :