Effect of Different Doses of Lutein and Zeaxanthin on Macular Pigment Optical Density

Osman Sayın , Hasan Altınkaynak

  • Osman Sayın: Sağlık Bilimleri Üniversitesi Konya Şehir Hastanesi
  • Hasan Altınkaynak: KONYA ŞEHİR HASTANESİ
  • Year : 2024
  • Vol : 40
  • Issue : 4
  •  Page : 166-170
ABSTRACT
Aim: To evaluate the effects of two different doses of lutein and zeaxanthin on macular pigment optical density (MPOD) in healthy subjects using heterochromatic flicker photometer (MPS II) method.
Materials and Methods: 20 right eyes of 20 healthy subjects were included in the study. The subjects were randomly divided into two groups with equal numbers. Group 1 received 5 mg lutein and 1 mg zeaxanthin supplements, while Group 2 received 10 mg lutein and 2 mg zeaxanthin supplements. MPOD values before and 1 month after supplementation were compared in Group 1 and Group 2 subjects.
Results: The mean age was 34.0±6.9 years in group 1 and 33.4±6.8 years in group 2. The mean MPOD values of the right eyes of the subjects in group 1 before and 1 month after supplement treatment were 0.41±0.09 and 0.41±0.10, respectively. The mean MPOD values of the left eyes of the subjects in group 1 before and 1 month after supplement treatment were 0.44±0.14 and 0.42±0.12, respectively. The mean MPOD values of the right eyes of the subjects in group 2 before and 1 month after supplement treatment were 0.39±0.10 and 0.37±0.11, respectively. The mean MPOD values of the left eyes of the subjects in group 2 before and 1 month after supplement treatment were 0.41±0.12 and 0.39±0.11, respectively. The values were not statistically significant (p>0.05).
Conclusion: In healthy subjects, 5 mg lutein and 1 mg zeaxanthin supplementation (Group 1) and 10 mg lutein and 2 mg zeaxanthin supplementation (Group 2) had no statistically significant effect on MPOD at 1 month.
Keywords: Hetereochromatic flicker photometer, lutein, macular pigment optical density, zeaxanthin
Cite this Article As : Sayin O, Altinkaynak H. Effect of Different Doses of Lutein and Zeaxanthin on Macular Pigment Optical Density. Selcuk Med J 2024;40(4): 166-170

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2024, Vol. 40 (4)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

References

  1. 1. Eisenhauer B, Natoli S, Liew G, et al. Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients. 2017;9(2). doi:10.3390/nu9020120
  2. 2. Edanur Arslan AMG. Lutein ve Zeaksantin. Sağlık ve Yaşam Bilimleri Dergisi. 2022;4(1):201-8. https://doi.org/10.33308/2687248X.202241233
  3. 3. Yabuzaki J. Carotenoids Database: structures, chemical fingerprints and distribution among organisms. Database (Oxford). 2017;2017(1). doi: 10.1093/database/bax004
  4. 4. Wilson LM, Tharmarajah S, Jia Y, et al. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis. Adv Nutr. 2021;12(6):2244-54. doi: 10.1093/advances/nmab071
  5. 5. Beatty S, Boulton M, Henson D, et al. Macular pigment and age related macular degeneration. Br J Ophthalmol. 1999;83(7):867-77. doi: 10.1136/bjo.83.7.867
  6. 6. Beatty S, Murray IJ, Henson DB, et al. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci. 2001;42(2):439-46.
  7. 7. Bernstein PS, Delori FC, Richer S, et al. The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders. Vision Res. 2010;50(7):716-28. doi: 10.1016/j.visres.2009.10.014
  8. 8. Johnson EJ, Avendano EE, Mohn ES, et al. The association between macular pigment optical density and visual function outcomes: a systematic review and meta-analysis. Eye (Lond). 2021;35(6):1620-8. doi: 10.1038/s41433-020-01124-2
  9. 9. Johnson EJ. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr Rev. 2014;72(9):605-12. doi: 10.1111/nure.12133.
  10. 10. Dawczynski J, Jentsch S, Schweitzer D, et al. Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study. Graefes Arch Clin Exp Ophthalmol. 2013;251(12):2711-23. doi: 10.1007/s00417-013-2376-6.
  11. 11. Ma L, Liu R, Du JH, et al. Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients. 2016;8(7). doi: 10.3390/nu8070426
  12. 12. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Jama. 1994;272(18):1413-20. doi:10.1001/jama.1994.03520180037032
  13. 13. Harikumar KB, Nimita CV, Preethi KC, et al. Toxicity profile of lutein and lutein ester isolated from marigold flowers (Tagetes erecta). Int J Toxicol. 2008;27(1):1-9. doi: 10.1080/10915810701876265.
  14. 14. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Jama. 2013;309(19):2005-15. doi:10.1001/jama.2013.4997
  15. 15. Nolan JM, Stack J, O'Connell E, et al. The relationships between macular pigment optical density and its constituent carotenoids in diet and serum. Invest Ophthalmol Vis Sci. 2007;48(2):571-82. doi: 10.1167/iovs.06-0864.
  16. 16. Curran-Celentano J, Hammond Jr BR, Ciulla TA, et al. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. The American journal of clinical nutrition. 2001;74(6):796-802. doi: 10.1093/ajcn/74.6.796.
  17. 17. Kelly ER, Plat J, Haenen GR, et al. The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial. PLoS One. 2014;9(3):e92659. doi: 10.1371/journal.pone.0092659
  18. 18. Kopsell DA, Lefsrud MG, Kopsell DE, et al. Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention. J Agric Food Chem. 2006;54(21):7998-8005. doi: 10.1021/jf0614802
  19. 19. Loughman J, Nolan JM, Howard AN, et al. The impact of macular pigment augmentation on visual performance using different carotenoid formulations. Invest Ophthalmol Vis Sci. 2012;53(12):7871-80. doi: 10.1167/iovs.12-10690.
  20. 20. Johnson EJ, Chung H-Y, Caldarella SM, et al. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. The American journal of clinical nutrition. 2008;87(5):1521-9. doi: 10.1093/ajcn/87.5.1521.
  21. 21. Thurnham DI, Nolan JM, Howard AN, et al. Macular response to supplementation with differing xanthophyll formulations in subjects with and without age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2015;253(8):1231-43. doi: 10.1007/s00417-014-2811-3.
  22. 22. Yoshizako H, Hara K, Takai Y, et al. Comparison of macular pigment and serum lutein concentration changes between free lutein and lutein esters supplements in Japanese subjects. Acta Ophthalmol. 2016;94(6):e411-6. doi: 10.1111/aos.13106.
  23. 23. Berrow EJ, Bartlett HE, Eperjesi F. The effect of nutritional supplementation on the multifocal electroretinogram in healthy eyes. Doc Ophthalmol. 2016;132(2):123-35. https://doi.org/10.1007/s10633-016-9532-3