Effect of Lupus Nephritis on Cardiac Remodeling and Left Ventricular Relative Wall Thickness

SEFA TATAR , AHMET TAHA ŞAHİN , Yunus Emre Yavuz, Hüseyin Özer, Bryan Nicolalde, Nuraiym Moloshova, MUSTAFA ÇAĞRI ERGÜN

  • SEFA TATAR: Necmettin Erbakan Üniversitesi Tıp Fakültesi
  • Yunus Emre Yavuz: Siirt Eğitim ve Araştırma Hastanesi
  • Hüseyin Özer: Norwalk Hospital
  • Bryan Nicolalde: Norwalk Hospital
  • Nuraiym Moloshova: Necmettin Erbakan Üniversitesi Tıp Fakültesi
  • MUSTAFA ÇAĞRI ERGÜN: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Year : 2025
  • Vol : 41
  • Issue : 2
  •  Page : 89-93
ABSTRACT
 Aim: Systemic Lupus Erythematosus (SLE) is an autoimmune disease associated with an increased risk of cardiovascular problems. Our objective is to investigate the effect of renal involvement in SLE on left ventricular relative wall thickness (RWT).
Materials and Methods: A single-center observational study was conducted to compare the echocardiographic characteristics of patients with SLE who had lupus nephritis and those without. A total of 125 patients were included in the study.
Results: The mean age was 31 years in patients with lupus nephritis and 40 years in those without. In patients with lupus nephritis, the interventricular septum thickness was found to be thinner. The Mitral A wave was lower in patients with lupus nephritis (62.5±17 vs. 74.9±20.5, p<0.05). Left ventricular relative wall thickness (RWT) was calculated to be lower in patients with lupus nephritis (0.38±0.06 vs. 0.43±0.07, p<0.05).
Conclusion: The development of lupus nephritis has a significant impact on myocardial function, and left ventricular RWT is an important parameter associated with adverse cardiovascular outcomes.
Keywords: Systemic Lupus Erythematosus, lupus nephritis, left ventricle, relative wall thickness, diastolic dysfunction
Cite this Article As : Tatar S, Sahin AT, Yavuz YE, Ozer H, Nicolalde B, Moloshova N, Ergun MC. Effect of Lupus Nephritis on Cardiac Remodeling and Left Ventricular Relative Wall Thickness. Selcuk Med J 2025;41(2): 89-93

Download Citation: Endnote/Zotero/Mendeley (RIS) RIS File

Download Citation: BibTeX BibTeX File

Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2025, Vol. 41 (2)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

References

  1. 1- Ryu S, Fu W, Petri MA. Associates and predictors of pleurisy or pericarditis in SLE. Lupus Sci Med 2017;4:e000221.
  2. 2- Yafasova A, Fosbøl EL, Schou M, Baslund B, Faurschou M, Docherty KF, et al. Long-term cardiovascular outcomes in systemic lupus erythematosus. J Am Coll Cardiol 2021;77:1717–1727.
  3. 3- Kim CH, Al-Kindi SG, Jandali B, Askari AD, Zacharias M, Oliveira GH. Incidence and risk of heart failure in systemic lupus erythematosus. Heart Br Card Soc 2017;103:227–233.
  4. 4- Karşıdağ, S., Çınar, N., & Şahin, Ş. Sistemik Lupus Eritematozusun Nörolojik Komplikasyonları: Olgu Serisi Temelinde Gözden Geçirme. Ş.E.E.A.H. Tıp Bülteni 2014;48(1):47-50
  5. 5- Ballocca F, D’Ascenzo F, Moretti C, Omedè P, Cerrato E, Barbero U, et al. Predictors of cardiovascular events in patients with systemic lupus erythematosus (SLE): a systematic review and meta-analysis. Eur J Prev Cardiol 2015;22:1435–1441.
  6. 6- Petri M. Epidemiology of the antiphospholipid antibody syndrome. J Autoimmun. 2000;15(2):145–51.
  7. 7- Lu X, Wang Y, Zhang J, Pu D, Hu N, Luo J, et al. Patients with systemic lupus erythematosus face a high risk of cardiovascular disease: a systematic review and metaanalysis. Int Immunopharmacol. 2021;94:107466.
  8. 8- Eguchi K, Ishikawa J, Hoshide S, Ishikawa S, Pickering TG, Schwartz JE, et al. Differential impact of left ventricular mass and relative wall thickness on cardiovascular prognosis in diabetic and nondiabetic hypertensive subjects. Am Heart J 2007; 154:79e9–15.
  9. 9- Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol 2011;58:1733–1740.
  10. 10- Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials: a report from the american society of echocardiography's guidelines and standards committee and the task force on echocardiography in clinical trials. Journal of the American Society of Echocardiography. 2004;17(10):1086-1119.
  11. 11- Chen J, Tang Y, Zhu M, Xu A. Heart involvement in systemic lupus erythematosus: a systemic review and meta-analysis, Clin. Rheumatol. 2016;36:2437–2448.
  12. 12- Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging, J. Am. Soc. Echocardiogr. Off. Publ. Am. Soc. Echocardiogr. 2016;29:277–314.
  13. 13- Li L, Xu H, Le Y, Li R, Shi Q, Zhu H, et al. Elevated serum levels of human epididymis protein 4 in adult patients with proliferative lupus nephritis. Frontiers in Immunology. 2023;14:1179986.
  14. 14- He W, Xie P, Li W, Yao F, Liu Y, Liang L, et al. Impaired left ventricular systolic synchrony in patients with lupus Nephritis: a speckle tracking echocardiography study. Lupus. 2022;31(9):1084-1093.
  15. 15- Gardin JM. The value of left ventricular relative wall thickness in predicting ventricular arrhythmia and related death. Journal of the American College of Cardiology 2016;67(3):313-315.
  16. 16- Hashem, M-Sherif, et al. "Left ventricular relative wall thickness versus left ventricular mass index in non-cardioembolic stroke patients." Medicine 94.20 (2015): e872.