Effects Of Angiotensin Blockers And Diuretic Combinations On Central Hemodynamics

In this study, effects of angiotensin blockers (ARB) and diuretics combinations on central hemodynamics and arteriyel stiffness parameters were analyzed. In this retrospective study, hemodynamical parameters of patients using ARB, ARB + diuretics and healthy controls were analyzed for 24 hours with Mobil-O-Graph Arteriograph (I.E.M. GmbH, Stolberg, Germany). 44 patients on ARB, 81 cases on ARB + diuretics and 30 healthy control subjects without any hypertension or chronic illness were included. Mean age of patients on ARB, ARB+ diuretics and control group were 51.2±15.8, 56.3±13.8, 53.4±15.9 respectively. 24 hour mean pulse pressure was correlated with 24 hour central systolic blood pressure (SBP) (r=0.646, p=0.02), and 24 hour reflection size (r=0.498, p=0.022). 24 hour central SBP was correlated with 24 hour Aix@75(r=0.590, p=0.005), cardiac output (r=0.630, p=0.005), peripheral resistance (r=0.451, p=0.030). 24 hour central diastolic BP (DBP) was correlated with 24 hour Aix@75 (r=0.445, p=0.040), cardiac output (r=0.798, p