Effects of nimodipine on tissue lactate and malondialdehyde levels in experimental head trauma* *

İn this study, we investigated the effects of nimodipine on tissue lactate (LA) and malondialdehyde (MDA) levels in rabbit brain one hour after experimental head trauma. The vveight drop method was used to produce head trauma in 25 Nevv-Zeland rabbits. The rabbits were divided into three groups Group 1 was the sham operated group. Group 2 (control group) received head trauma only and in group 3 nimodipine was administered 20 pgr./kg (i. v) immediately after the head trauma via the jugular vein. İn group 2 and 3 samples from the non contused side was named as "a" and contused side as "b". The tissue mean LA and MDA levels vvere 15.33+1.89 micromoles per gram wet vveight (pmol/gvvvv) and 66.21 ± 8.69 nanomoles per gram wet vveight (nmol/gww) in group 1, 18.24±1.84 //mol/gvvvv and 89.64 ± 9.65 nmol/gvvvv in group 2a, 25.50+1.78pmol/gww and 142.43±8.69 nmol/gww in group 2b, 18.67±1.81 pmol/gww and 91.09±11.86 nmol/gvvvv in group 3a, and 25.25±1.95 pmol/gvvvv and 137.60±9.59 nmol/gvvvv in group 3b respectively. The results vvere found similar betvveen the group 2 and 3. These results demonstrated that nimodipine has no effect on tissue LA and MDA levels in the early period of experimental head trauma.