Effeets of some divalent cations (Mn2+, Cd2+) on the contraction of frog lower oesophageal cir-cular strips indueed by Ca2+ in Ca2+ - free EDTA eontaining mediurn

Yusuf Karataş, Kansu Büyükafşar, Peyman Uçar, Şerare Atçı, ERGİN ŞİNGİRİK, Atilla Dikmen, Serpil Önder, Firuz Baysal

  • Yusuf Karataş: Çukurova Üniversitesi Tıp Fakültesi
  • Kansu Büyükafşar: Çukurova Üniversitesi Tıp Fakültesi
  • Peyman Uçar: Çukurova Üniversitesi Tıp Fakültesi
  • Şerare Atçı: Çukurova Üniversitesi Tıp Fakültesi
  • ERGİN ŞİNGİRİK: ÇUKUROVE ÜNİV
  • Atilla Dikmen: Çukurova Üniversitesi Tıp Fakültesi
  • Serpil Önder: Çukurova Üniversitesi Tıp Fakültesi
  • Firuz Baysal: Çukurova Üniversitesi Tıp Fakültesi
  • Year : 1997
  • Vol : 13
  • Issue : 1
  •  Page : 1-7
Ejjects of Mn2+ and Cd2+ vere investigated on the contracture induced hy I mM CaCl2 in the iso-lated frog lower oesophageal circular segments in-cuhated irt Ca2+ free Ringer solution containing 20 mM KCl and 0.01 mM Na2EDTA, Roth Mn2+ and Cd2+ inhibited the contractures in a can-•entration dependent manner. Cd2+ was found to be more patent than Mn2+ on the Ca2+ induced c:ont-racture. These findings indicated that Cd2+ and Mn2+ can block Ca2+ entry from extracellular space ta intracellulat- compartment.

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1997, Vol. 13 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :