Evaluation Of Hemostatic System In Patients With Arteriovenous Fistula Thrombosis On Hemodialysis

Hemodialysis patients have a tendency toward to thrombosis. AVF thrombosis is frequent in those patients. Study was aimed to evaluate patients by means of hemostatic state at our study, hemostatic parameters in haemodialysis patients with respect to healthy group were evaluated. Haemodialysis group (HDG) consisted of 45 patients (27 male, 18 female) and control group (CG) consisted of 15 healthy persons (8 male, 7 female). These parameters were evaluated whether contributing to thrombosis APC resistance is found to be higher in patient group. AT III and tPA antigen levels are low in patient group, while vWF antigen levels are high in patients with AVF problem compared to healthy subjects. Hypofibrinolysis and prethrombotic state were thought to play role in contributing vascular endothelial injury and AVF thrombosis. These findings reflect the pre-trhrombotic state and injured vascular endothelium in HDG with AVF problems. Thus, Hemodialysis patients must be screened and evaluated by means of pre-thrombotic events for better AVF survival and outcome.