Exploring the Link Between Serum Magnesium Levels and Acne Vulgaris Severity

MAHMUT SAMİ METİN , Tuğba Tehçi , İlkay Kolukırık , Serkan Akoğul , Zuhal Metin, Defne Özkoca

  • MAHMUT SAMİ METİN: Adana Şehir Eğitim ve Araştırma Hastanesi
  • Tuğba Tehçi: Adana Şehir Eğitim ve Araştırma Hastanesi
  • İlkay Kolukırık: Adana Şehir Eğitim ve Araştırma Hastanesi
  • Serkan Akoğul: Pamukkale Üniversitesi
  • Zuhal Metin: Kırşehir Ahi Evran Üniversitesi
  • Defne Özkoca: Koç Üniversitesi
  • Year : 2026
  • Vol : 42
  • Issue : 1
  •  Page : 21-26
Objective: Acne vulgaris is a prevalent long-term inflammatory skin disorder that notably impacts the quality of life, especially in teenagers and young adults.
Although the pathogenesis of acne is influenced by multiple factors, the contribution of micronutrients like magnesium is not yet fully elucidated. This study sought
to explore the relationship between serum magnesium concentrations and the severity of acne as assessed by the Global Acne Grading System (GAGS).
Materials and Methods: A case-control study with a prospective design was carried out at a single center between March and August 2023, including 60 individuals
diagnosed with acne vulgaris and 60 healthy controls matched by age and sex, all between 18 and 30 years old. The severity of acne was evaluated using the GAGS and
classified as mild, moderate, or severe. Serum magnesium levels were determined through the Xylidyl Blue colorimetric assay. Data were analyzed using SPSS version
29. For continuous variables not normally distributed, the Kruskal–Wallis H test was employed, with statistical significance defined as p < 0.05.
Results: The study included 34 female and 26 male acne patients and 31 female and 29 male healthy controls. No statistically significant differences were observed
in serum magnesium levels among acne severity groups or between patients and controls (p > 0.05). Although the moderate acne group had slightly higher mean
magnesium levels compared to mild and severe groups, the differences were not statistically significant. Magnesium concentrations remained within normal limits
across all groups.
Conclusion: Our results indicate that there is no significant association between serum magnesium levels and the severity of acne. While systemic magnesium
seems to have a limited role in the pathogenesis of acne, topical magnesium preparations might provide therapeutic advantages due to their anti-inflammatory and
antimicrobial properties. Further studies are necessary to better understand its efficacy.
Cite this Article As : Metin MS, Tehci T, Kolukirik I, Akogul S, Metin Z, Ozkoca D. Exploring the Link Between Serum Magnesium Levels and Acne Vulgaris Severity. Selcuk Med J 2026;42(1): 21-26

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2026, Vol. 42 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

References

  1. 1. Chilicka K, Gold MH, Nowicka D. Acne vulgaris and the most popular and new cosmetological treatments. J Cosmet Dermatol. 2023;22(7):1946-50. doi: 10.1111/jocd.15757.
  2. 2. Tan JK, Bhate K. A global perspective on the epidemiology of acne. Br J Dermatol. 2015;172(1):3-12. doi: 10.1111/bjd.13462.
  3. 3. Vasam M, Korutla S, Bohara RA. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology-based advances. Biochem Biophys Rep. 2023;36: 101578. doi: 10.1016/j.bbrep.2023.101578.
  4. 4. Tan AU, Schlosser BJ, Paller AS. A review of diagnosis and treatment of acne in adult female patients. Int J Womens Dermatol. 2017;4(2):56-71. doi: 10.1016/j.ijwd.2017.10.006.
  5. 5. Conforti C, Giuffrida R, Fadda S, et al. Topical dermocosmetics and acne vulgaris. Dermatol Ther. 2021;34(1): e14436. doi: 10.1111/dth.14436.
  6. 6. Jeremy AH, Holland DB, Roberts SG, et al. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol. 2003;121(1):20-7. doi: 10.1046/j.1523-1747.2003.12321. x.
  7. 7. Ibbotson SH, Dawe RS. Skin disease. In: Walker B, et al. (Eds.) Davidson’s Principles & Practice of Medicine 22nd (Edn.), Churchill Livingstone Elsevier, Edinburgh, 2014:1281-2.
  8. 8. Witkowski JA, Parish LC. The assessment of acne: an evaluation of grading and lesion counting in measuring acne. Clin Dermatol. 2004;22(5):394-7. doi: 10.1016/j.clindermatol.2004.03.008.
  9. 9. Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997;36(6):416-8. doi: 10.1046/j.1365-4362.1997.00099. x.
  10. 10. Aksoy H, Önder M. Aknede Şiddet Değerlendirmesi. Türkderm Türk deri hastalıkları ve frengi arşivi. 2020;54(1):16-9. doi: 10.4274/turkderm.galenos.2020.05882.
  11. 11. Sardana K, Sachdeva S. Role of nutritional supplements in selected dermatological disorders: A review. J Cosmet Dermatol. 2022;21(1):85-98. doi: 10.1111/jocd.14436.
  12. 12. Lakdawala N, Babalola O 3rd, Fedeles F, McCusker M, Ricketts J, et al. The role of nutrition in dermatologic diseases: facts and controversies. Clin Dermatol. 2013;31(6):677-700. doi: 10.1016/j.clindermatol.2013.05.004.
  13. 13. Pappas A, Liakou A, Zouboulis CC. Nutrition and skin. Rev Endocr Metab Disord. 2016;17(3):443-8. doi: 10.1007/s11154-016-9374-z.
  14. 14. Sayyafan MS, Ramzi M, Salmanpour R. Clinical assessment of topical erythromycin gel with and without zinc acetate for treating mild-to-moderate acne vulgaris. J Dermatolog Treat. 2020;31(7):730-3. doi: 10.1080/09546634.2019.1606394.
  15. 15. Yee BE, Richards P, Sui JY, et al. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33(6): e14252. doi: 10.1111/dth.14252.
  16. 16. Fiorentini D, Cappadone C, Farruggia G, et al. Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency. Nutrients. 2021;13(4):1136. doi: 10.3390/nu13041136.
  17. 17. Saris NE, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical, and analytical aspects. Clin Chim Acta. 2000;294(1-2):1-26. doi: 10.1016/s0009-8981(99)00258-2.
  18. 18. Barbagallo M, Veronese N, Dominguez LJ. Magnesium in Aging, Health, and Diseases. Nutrients. 2021;13(2):463. doi: 10.3390/nu13020463.
  19. 19. Tamara A, Anggowarsito, JL, Tandyono V. Association between magnesium levels and the severity of acne vulgaris. Journal of Widya Medika Junior. 2021; 3:237-41. doi: https://doi.org/10.33508/jwmj.v3i4.3504
  20. 20. Jaripur M, Ghasemi-Tehrani H, Askari G, et al. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial. Reprod Biol Endocrinol. 2022;20(1):110. doi: 10.1186/s12958-022-00982-7.
  21. 21. Saleh BO, Anbar ZN, Majid AY. Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients. Journal Clinical and Experimental Dermatology Research. 2013;4(1):1-4. doi: 10.4172/2155-9554.1000169.
  22. 22. Salma A, Rubaiya A, Islam R, et al. Effect of Serum Trace Elements, Macro-minerals and Antioxidants in Acne Vulgaris Patients: A Case-Control Study. Dhaka University Journal of Pharmaceutical Sciences. 2016; 15:215-20. doi: https://doi.org/10.3329/dujps.v15i2.30940
  23. 23. González-Mondragón EA, Ganoza-Granados LDC, Toledo-Bahena ME, et al. Acne and diet: a review of pathogenic mechanisms. Bol Med Hosp Infant Mex. 2022;79(2):83-90. doi: 10.24875/BMHIM.21000088.
  24. 24. Bernales Salinas A. Acne vulgaris: role of the itera system. Int J Dermatol. 2021;60(9):1076-81. doi: 10.1111/ijd.15415.
  25. 25. Dréno B, Pécastaings S, Corvec S, et al. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018;32(Suppl 2):5-14. doi: 10.1111/jdv.15043.
  26. 26. Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to itera function. Ann Nutr Metab. 2007;51(4):301-23. doi: 10.1159/000107673.
  27. 27. Kiani AK, Dhuli K, Donato K, et al. Main nutritional deficiencies. J Prev Med Hyg. 2022;63(2 Suppl 3):93-101. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2752.
  28. 28. Burris J, Rietkerk W, Woolf K. Relationships of self-reported dietary factors and perceived acne severity in a cohort of New York young adults. J Acad Nutr Diet. 2014;114(3):384-92. doi: 10.1016/j.jand.2013.11.010.
  29. 29. Fukada T, Yamasaki S, Nishida K, et al. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem. 2011;16(7):1123-34. doi: 10.1007/s00775-011-0797-4.
  30. 30. Cervantes J, Eber AE, Perper M, et al. The role of zinc in the treatment of acne: A review of the literature. Dermatol Ther. 2018;31(1). doi: 10.1111/dth.12576.
  31. 31. Liu H, Yu H, Xia J, et al. Topical azelaic acid, salicylic acid, nicotinamide, sulfur, zinc and fruit acid (alpha-hydroxy acid) for acne. Cochrane Database Syst Rev. 2020;5(5):CD011368. doi: 10.1002/14651858.CD011368.
  32. 32. Rude RK, Ross AC, Caballero B, et al. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams &Wilkins; 2012:159-75.
  33. 33. Chandrasekaran NC, Weir C, Alfraji S, et al. Effects of magnesium deficiency more than skin deep. Exp Biol Med (Maywood). 2014;239(10):1280-91. doi: 10.1177/1535370214537745.
  34. 34. Welch K, Latifzada MA, Frykstrand S, et al. Investigation of the Antibacterial Effect of Mesoporous Magnesium Carbonate. ACS Omega. 2016;1(5):907-14. doi: 10.1021/acsomega.6b00124.
  35. 35. Fabbrocini G, Donnarumma M, Russo G, et al. Effectiveness of supplementation with myo-inositol, folic acid and liposomal magnesium in male insulin-resistant patients with acne. Esperienze Dermatol. 2016;18(2):76–9.
  36. 36. Marina K, Vyacheslav C. Acne treatment in patients with connective tissue dysplasia. Medical news of the North Caucasus. 2014;9(2):170-2. doi: http://dx.doi.org/10.14300/mnnc.2014.09048.
  37. 37. Li M, Tang Y, Lin C, et al. Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study. Biol Trace Elem Res. 2017;176(1):73-80.