Frequency of consanguinity, karyotype distribution and sex ratio of cases with trisomy 21

Sennur Demirel, AYNUR ACAR, TÜLİN ÇORA, HATİCE GÜL DURSUN, AYŞEGÜL ZAMANİ, HASAN ACAR

  • Sennur Demirel: Selçuk Üniversitesi Meram Tıp Fakültesi
  • AYNUR ACAR: SELÇUK ÜNİVERSİTESİ
  • TÜLİN ÇORA: SELÇUK ÜNİVERSİTESİ
  • HATİCE GÜL DURSUN: SELÇUK ÜNİVERSİTESİ
  • AYŞEGÜL ZAMANİ: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • HASAN ACAR: SELÇUK ÜNİVERSİTESİ
  • Year : 1998
  • Vol : 14
  • Issue : 4
  •  Page : 165-168
This study included 126 Down syndrome cases (81 males and 45 females) who had regular trisomy 21 in 120 cases, chromosome 21q trisomy in 5 and a mosaic karyotype in one case. The ratio of males to females was found to be 2:1 in regular trisomy 21 and 1:4 in chromosome 21q trisomy. The study implicated that trans-locations that were found were mostly matemal in origin. it is alsa noteworthy that the frequency of consanguinity among the parents having children with Down syndrome (21.6%) was not different from the population fre-quency in Konya (23.2%). Moreover, the mean age of ~her having children with Down syndrome was de-termined to be 30.7

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1998, Vol. 14 (4)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :