Geriatrik Hastalarda Hafif Bilişsel Bozuklukla İlişkili Olabilecek Periferik Biyobelirteçler

Okan İMRE , Ömer ACAT , Mustafa KARAAĞAÇ , Fatih EKİCİ , Rahim Kocabaş

  • Okan İMRE: Karamanoğlu Mehmetbey Üniversitesi
  • Ömer ACAT: Karamanoğlu Mehmetbey Üniversitesi Tıp Fakültesi
  • Mustafa KARAAĞAÇ: Karamanoğlu Mehmetbey Üniversitesi Tıp Fakültesi
  • Fatih EKİCİ: SELÇUK ÜNİVERSİRESİ TIP FAKÜLTESİ
  • Rahim Kocabaş: karaman üniversitesi
  • Year : 2025
  • Vol : 41
  • Issue : 1
  •  Page : 42-48
Amaç: Hafif bilişsel bozukluk (HBB), bilişsel fonksiyonlarda azalmanın olduğu, erken müdahale edilmediği takdirde işlevsellikte kayıpların yaşandığı bir bozukluktur. Bu çalışmadaki amacımız HBB ile kontrol grubu arasında, nötrofil/yüksek- yoğunluklu lipoprotein kolesterol (HDLc) düzeyi oranı (NHO), monosit/HDLc oranı (MHO), ürik asit/HDLc oranı (UHO)’nı kıyaslamak ve bu parametrelerin HBB için prediktör bir biyobelirteç olarak kullanılıp kullanılamayacağını araştırmaktır.
Gereç ve Yöntemler: Kesitsel olan bu çalışmada 65 yaş üstü kişilerden ICD-10’a göre HBB tanısı konulan 68 kişi hasta grubunu oluşturdu. Kontrol grubu 65 yaş üzeri mental yeterlilik değerlendirmesi sonucu HBB olmayan bireylerden seçildi.
Bulgular: Monosit, UHO ve MHO seviyelerinin HBB grubunda daha yüksek olduğu görüldü (sırasıyla; p= 0.036, p= 0.007, p= 0.004). Mini-Mental Durum Muayene (MMSE) skoru ile HDLc seviyeleri arasında pozitif (p= 0.032), UHO arasında negatif yönlü ilişki (p= 0.019) bulundu. Tanı durumunu tahmin etmede UHO cut-off değeri= 0.1285 alındığında duyarlılığın %41.9 ve özgüllüğün %80.3 olduğu bulundu. MHO için cut-off değeri= 0.125 alındığında duyarlılığın %40.3 ve özgüllüğün %78.9 olduğu görüldü.
Sonuç: Düşük duyarlılık ve özgüllükte olsa da HBB tanısını tahmin etmede UHO ve MHO anlamlı bulundu. MMSE skoru ile HDLc seviyeleri arasındaki pozitif yönlü ilişki bulunması HDLc’nin bilişsel fonksiyonlara karşı koruyucu olabileceğini göstermektedir. UHO arttıkça MMSE skorunun düşmesi, UHO’nun prognozda kullanılabileceğine işaret edebilir. Çalışma sonuçlarımızın ileriye dönük çalışmalarla desteklenmesi gerekir.
Anahtar Kelimeler: Geriatri, mini-mental durum, bilişsel işlev, monosit/HDLc oranı, ürik asit/HDLc oranı
Cite this Article As : Imre O, Acat O, Karaagac M, Ekici F, Kocabas R. Peripheral Biomarkers That May Be Associated with Mild Cognitive Impairment in Geriatric Patients. Selcuk Med J 2025;41(1): 42-48

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2025, Vol. 41 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

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