Management Of High Risk Essential Thrombocythemia In Pregnant With Recurrent Pregnancy Loss

Essantial Thrombocythemia (ET) is a disease characterized by an increased platelets count, megakaryocyte hyperplasia and increased thrombotic or hemorrhagic events. ET is frequent in women and 15-20% of patients with ET are diagnosed in childbearing age. Pregnancy loss is more in patients with ET than normal population. Early pregnancy loss occurs in 1/3 of patients with ET. We present a women, with ET complicated with portal vein thrombosis who had 3 early and 1 late pregnancy loss with hydroxyurea treatment. She had live birth after treatment with interferonalfa (IFN-α) and low molecular weight heparin (LMWH). Aims of treatment of pregnant women with ET prevent of maternal complications and pregnancy loss due to vasooclusive events. Thus, treatment with IFN-α, aspirin and LMWH are safe and improve pregnancy outcomes.