P glycoprotein expression in fine needle aspiration specimens from lymp nodes of non-hodgkin’s lymphoma

Bahriye Payzin, Melek Üstün, Ayhan Kılıç, Binnur Önal, Arzu Avcı, Dilek Soysal

  • Bahriye Payzin: Atatürk Eğitim ve Araştırma Hastanesi
  • Melek Üstün: Atatürk Eğitim ve Araştırma Hastanesi
  • Ayhan Kılıç: Atatürk Eğitim ve Araştırma Hastanesi
  • Binnur Önal: SSK Dışkapı Eğitim ve Araştırma Hastanesi
  • Arzu Avcı: Atatürk Eğitim ve Araştırma Hastanesi
  • Dilek Soysal: Atatürk Eğitim ve Araştırma Hastanesi
  • Year : 2002
  • Vol : 18
  • Issue : 3
  •  Page : 177-183
We studied P glycoprotein (Pgp) expression by testing fine needle aspiration specimens from lymp nodes with C- 494 antibody using an immunocytochemical assay in 30 cases of hlstologically proven non-Hodgkin’s lymphoma (NHL) at diagnosis and after three courses of chemotherapy. Pgp expression was detected İn two of eight patients with stage l-ll, 10 of 22 patients with stage lll-IV at diagnosis and in one of two patients with stage l-ll, three of eight patients with stage lll-IV after chemotherpy. The stage of disease, the presence of B symptoms, the rate of response to treatment and duration of overall survival showed no significant difference between the group of Pgp negative patients ad the group of Pgp positive patients. İn conclucion we suggest that Pgp expression alone can not explain the treatment of chemotherapy resistance in NHL probably due to multifuctorial mechanisms of drug resistance.

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2002, Vol. 18 (3)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :