Papiller Benzeri Nükleer Özellikler Gösteren Noninvaziv Foliküler Tiroid Neoplazilerinde Eşlik Eden Papiller Tiroid Karsinomu için Preoperatif Öngördürücü Faktörler

MUHAMMET KOCABAŞ, YUSUF ÖZTÜRK

  • MUHAMMET KOCABAŞ: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • YUSUF ÖZTÜRK: Sakarya University, Faculty of Medicine
  • Year : 2026
  • Vol : 42
  • Issue : 1
  •  Page : 50-57
Amaç: Papiller benzeri nükleer özellikler gösteren noninvaziv foliküler tiroid neoplazisi (NIFTP) olgularının klinik, ultrasonografik ve sitolojik özelliklerini değerlendirmek
ve papiller tiroid karsinomunun (PTK) eşlik etmesi ile ilişkili preoperatif faktörleri belirlemek.
Gereç ve Yöntemler: Bu retrospektif çalışmaya tiroidektomi sonrası histopatolojik olarak NIFTP tanısı konulan 115 hasta dâhil edildi. Demografik, ultrasonografik,
sitolojik ve patolojik veriler analiz edildi. Nodüller, Avrupa Tiroid Görüntüleme Raporlama ve Veri Sistemi (EU-TIRADS) ve Bethesda sitoloji sınıflamasına göre
değerlendirildi. Hastalar “PTK eşlik eden NIFTP” ve “PTK eşlik etmeyen NIFTP” olarak iki gruba ayrıldı. Eşzamanlı PTK’yi öngördüren faktörleri belirlemek için
karşılaştırmalı ve lojistik regresyon analizleri yapıldı.
Bulgular: Hastaların ortalama yaşı 46.78±13.98 yıl olup %74.8’i kadındı. NIFTP nodüllerinin ortalama boyutu 23.15±16.70 mm idi. EU-TIRADS sınıflamasına göre
nodüllerin %44.3’ü kategori 3, %14.8’i kategori 4 ve %37.4’ü kategori 5 olarak değerlendirildi. Sitoloji sonuçları en sık Bethesda I (%27.0), II (%32.2) ve III (%24.3) olarakraporlandı. Otuz üç hastada (%28,7) eşzamanlı PTK saptandı. Tek değişkenli analizde küçük nodül boyutu (OR 0.956, %95 GA 0.924–0.990, p=0.010) eşlik eden PTK ile anlamlı şekilde ilişkili bulunurken, EU-TIRADS kategori 5 (OR 2.288, 95% GA 1.002-5.228, p=0.050) sınırda anlamlılık gösterdi. Çok değişkenli analizde ise yalnızca küçük
nodül boyutu bağımsız bir öngördürücü olarak kaldı (OR 0.951, 95% GA 0.909-0.995, p=0.030).
Sonuç: NIFTP olgularında, daha küçük nodül boyutu eşlik eden PTK’nin bağımsız bir öngördürücüsü olarak saptanırken; solid kompozisyon, halo varlığı veya yüksek
EU-TIRADS skorları gibi şüpheli sonografik özellikler ise bağımsız öngördürücüler olarak bulunmadı. Küçük nodüllerin dikkatli değerlendirilmesi, preoperatif risk
sınıflandırmasının geliştirilmesine ve cerrahi karar sürecinin yönlendirilmesine katkı sağlayabilir.
Cite this Article As : Kocabas M, Ozturk Y. Preoperative Predictors of Coexistent Papillary Thyroid Carcinoma in Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features. Selcuk Med J 2026;42(1): 50-57

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2026, Vol. 42 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

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