Phospholipid Solutions for Prevention of Intraperitoneal Adhesions

Aim: In this study we aimed to analyze effects of phospholipid solutions (preventing adhesions by increasing slipperiness between damaged surfaces and detaching them) during peritoneal reepitelization. Material and Method: Thirty Wistar Albino type rats divided in two groups. Caecum serosa was damaged using sterile gauzes to achive light serosal haemorrhagy and 1 cm2 of periton excised from right side of abdominal wall in all rats.Group I was applied 3 ml %0.9 NaCl and Group II was applied phospholipid solution (Fresnius Kabi – Deustchland) intrabdominally before closure. Rats sacrified at postopertive 10th day. After macroscopically examining adhesions, adhesion surfaces were calculated with a calibration scale. In microscopic examination lymphocytes, plasma cells, polymorphonuclear cells, histiocytes and fibroblasts were marked and counted with Clemex Image Analysis system. Results: In phospholipid group there was a significant decrease in adhesion formation compared to control group macroscopically. The decrease in adhesion formation was statistically significant (p<0.05). There were also significant differences between two groups in microscopically observed fibroblast and PMNL ratios and this difference was also statistically significant. Conclusions: Usage of phopholipid solutions decreases postoperative adhesions. Application of phospholipid solutions is a cost-effective method for preventing consequent operations for intraabdominal adhesions.