Pilomatrix Carcinoma

Aim: It was aimed to discuss a rare case which was diagnossed as pilomatrix carcinoma. Case Report:We report the case of a 50-year- old man with a pilomatrix carcinoma in his left forearm. In his history the patient announced taht the lesion had developed one year ago, and its size had expanded rapidly after the first six- month period. Diagnosis of malignant pilomatricoma is essentially histopathological .The tumor was composed of pleomorphic basaloid cells with prominent nucleoli and frequent atypical mitoses accompanied by central areas with keratotic materials, shadow cells, and foci of necrosis. Vascular or perineural infiltration was not observed. The patient remained disease-free at the 22 months follow- up. Conclusion: Pilomatrix carcinoma is a neoplasm of low-grade malignancy that should be distinguished from the conventional pilomatrixoma and its variants. Clinicians and pathologists should be aware of the occurrence of pilomatrix carcinoma because of its potential for distant metastases. We reviewed the literature and comment on the histopathologic differences from other cutaneous tumors.