ABSTRACT Aim: Bone is a tissue in which metastasis of the primary tumor is common in oncological patients. In our study, we aimed to evaluate the clinical and pathological features and survival status of patients with histopathological bone metastases. Materials and Methods: Hematoxylin-eosin and immunohistochemical stained preparations of materials belonging to 107 patients diagnosed with metastatic tumors in bone between 2010 and 2023 in our pathology department were evaluated retrospectively. Age, gender, survival, and clinical outcomes of the patients were obtained from hospital records. Primary focus, localization of the tumor, histopathological features of the tumor, and survival status of the patients were evaluated retrospectively. Results: The ages of 107 patients ranged from 36 to 84; 61 of them were men and 46 were women. The tumor that most frequently metastasized to the bone was lung malignancy (32.7%; n=35), followed by breast malignancy (22.4%; n=24). It was determined that 35.5% of the patients (n = 38) were initially diagnosed with metastasis. Metastasis was mostly observed in the femur bone (65.4%). In the five-year survival analysis, survival was observed to be shortest (12 months) in metastasis of adenoid cystic carcinoma of the salivary gland and longest (60 months) in colorectal, prostate and thyroid tumors. Conclusion: It was determined that the most common metastasis in bone was in the femur, and rarely in atypical areas. Although metastasis was most common in adenocarcinoma morphology, it could also be in a different morphology such as carcinosarcoma. It was observed that some of the patients were initially diagnosed with metastasis and rarely the primary focus could not be determined. When evaluating tumor-containing bone materials, it should be kept in mind that metastases can present with a wide variety of localizations and morphologies. Keywords: Bone, metastases, histopathology, malignant tumor
Cite this Article As :
Erkilinc G, Tan A, Tosyali HK, Temiz P. 13 Year Retrospective Analysis of Tumors Metastasizing to Bone. Selcuk Med J 2024;40(2): 49-56
1. Chin H, Kim J. Bone metastasis: concise overview. Federal Practitioner. 2015; 32(2):24.
2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin. 2009; 59(4):225-49.
3. Weilbaecher KN, Guise TA, McCauley LK. Cancer to bone: a fatal attraction. Nature Reviews Cancer. 2011; 11(6):411-25.
4. Hirabayashi H, Ebara S, Kinoshita T, et al. Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases. Cancer. 2003; 97(2):476-84.
5. Esposito M, Guise T, Kang Y. The biology of bone metastasis. Cold Spring Harb Perspect Med. 2018; 8(6).
6. Bhandari V, Jain RK. A retrospective study of incidence of bone metastasis in head and neck cancer. J Cancer Res Ther. 2013; 9(1):90-3.
7. Coleman R.E. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006; 12(20):6243S-9S.
8. Coleman R. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev. 2001; 27(3):165-76.
9. Desai S, Jambhekar N. Clinicopathological evaluation of metastatic carcinomas of bone: a retrospective analysis of 114 cases over ten years. Indian J Pathol Microbiol. 1995; 38(1):49-54.
10. Body J-J. Metastatic bone disease: clinical and therapeutic aspects. Bonnet. 1992; 13:S57-S62.
11. Baliyan A, Punia RS, Kundu R, et al. Histopathological spectrum of bone changes in skeletal metastasis. Indian J Med Paediatr Oncol. 2019; 40(04):476-80.
12. Selvaggi G, Scagliotti GV. Management of bone metastases in cancer: a review. Crit Rev Oncol Hematol. 2005; 56(3):365-78.
13. Hui M, Balu B, Uppin SG, et al. Bone metastases: A compilation of 365 histologically verified cases spanning over two decades from a single center. Indian J Pathol Microbiol. 2021; 64(4):717.
14. Kotwall CA. Breast cancer treatment and chemoprevention. Can Fam Physician. 1999;45:1917.
15. Choi J, Raghavan M. Diagnostic imaging and image-guided therapy of skeletal metastases. Cancer Control. 2012; 19(2):102-12.
16. Coca P, Gundeti S, Uppin S, et al. Metastatic adenocarcinoma in a young male, 12 years after treatment of primary non-seminomatous germ cell tumor. Indian J Med Paediatr Oncol. 2011; 32(02):115-7.
17. O'Sullivan GJ, Carty FL, Cronin CG. Imaging of bone metastasis: an update. World journal of radiology. 2015; 7(8):202.
18. Holmes FF, Fouts TL. Metastatic cancer of unknown primary site. Cancer. 1970; 26(4):816-20.
19. Errani C, Mavrogenis AF, Megaloikonomos PD, et al. Immunohistochemical evaluation of bone metastases. Nowotwory Journal of Oncology. 2017; 67(1):1-6.
20. Kerin R. The hand in metastatic disease. The Journal of Hand Surgery. 1987; 12(1):77-83.
21. Ahmadreza A, Payam F, Hamidreza K. Metastases to the hand and wrist: an analysis of 221 cases.The Journal of hand surgery, 2014, 39.5: 923-932.
Keywords
