The Comparisian Of The Effects Of Thi-opentone With Propofol On The Immune System

The Comparisian Of The Effects Of Thi-opentone With Propofol On The Immune System By using TIVA technique first group patients were infused with propofol (2 mglkg for induction, 6-12 niglkg1hr for maintenance) and second group infused with thiopentone (3-5 mglkg for induction, 7 mglkglhr for maintenance). Anaesthetic gas was not given. Many immunological (IgG. 1gM, IgA, C3-C4, CD4 and CD8) and haematological (leucocyte, het, fib, blood smear and lymphocyte counts) testes were studied on samples obtained 30 min. before. 30 min. and 24 hr after the operation.Thc im-munoglohulin and complement were studied by radial immunodiffusion technique and CD4-CD8 were stu-died by immunoflorescence + monoclonal antibodies technique. The ppd test was also implemented before and after two days of anaesthesia. In the study at pos-toperative 30 WI min decrease of IgG. IgM. IgA and C3 in the group used propofol and decrease of IgM. IgA and C4 in the group used thiopentone were sig-nificant. At postoperative 24 'di hours increase of the IgG, IgM and C3 levels and decrease of IgA level in the first group and decrease of the IgA level