The effect of clarithromycin on the Isolated pregnant women myometrlum contracted by oxytocln

The aim of this study was to investigate the effect of clarithromycin on the isolated pregnant human myometrium contracted by oxytocin. The myometrium strips (15X3 mm in size) were obtained during caesarean section. Different concentration of drug; 0.5 mg/ml (Group I) and 1 mg/ml (Group II) was used and no drug was applied to the placebo group (Group III). The two different doses of clarithromycin inhibited the amplitudes, the inhibition was dose and time dependent. Hovvever the frequency was increased independent of dose and time. No changes was observed in both amplitude and frequency of the placebo group. İn conclusion, clarithromycin dose dependently inhibits the amplitude of contractions but also increases frequency of contractions induced by oxytocin in human myometrial strips in vitro.