THE EFFECTS OF NIFEDIPINE ON PULMONARY ARTERIAL ATRIAL NATRIURETIC PEPTIDE IN CHRONIC HYPDXEMIC PATIENTS WITH PULMONARY HYPERTENSION

MECİT SUERDEM, Hüseyin Şenocak, Ramazan Yiğitoğlu, Ümit Özbek, Sebahattin Ateşal, Ebubekir Bakan

  • MECİT SUERDEM: SELÇUK ÜNİVERSİTESİ
  • Hüseyin Şenocak: Atatürk Üniversitesi Tıp Fakültesi
  • Ramazan Yiğitoğlu: Atatürk Üniversitesi Tıp Fakültesi
  • Ümit Özbek: Atatürk Üniversitesi Tıp Fakültesi
  • Sebahattin Ateşal: Atatürk Üniversitesi Tıp Fakültesi
  • Ebubekir Bakan: Atatürk Üniversitesi Tıp Fakültesi
  • Year : 1992
  • Vol : 8
  • Issue : 4
  •  Page : 617-621
Nifedipide was giren, 10 ıng sublingually. ta 21 patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), anıl its ellects on hemodynamics, and pulmonary arterial atrial natriuretic peptide (ANP) level were in-vestigated during right hecin catheterization. The le-reis of ANI' correlaied di•erıly wiıiı metin pul-monary arterial pressure (r=0.50;p<0.05) and ri,.4la atrial pressure (r=0.47,p<0.05). After nifedipine, mi si,fpufleant changes were observed in mean pul-~naly arterial, right atrial, and pulmonar capillary wedge pressure. Ilowever, the nifedipine caused an increase in the media!, pulmonary arterial plasma ANI' levet from 127.9 to 21153 pglınl (p<0.05). These dara indicate that nifedipine is a stimıdus for AN? release in patients with COPD.

Download Citation: Endnote/Zotero/Mendeley (RIS) RIS File

Download Citation: BibTeX BibTeX File

Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1992, Vol. 8 (4)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :