The Evaluation of Nasal Polyps in Terms Of Cigarette Smoking, Proliferative Processes, and Inflammation: Cross-Sectional Study

ETHEM ÖMEROĞLU , AYŞE NUR UĞUR KILINÇ, Zeynep BAYRAMOĞLU, MD, YAŞAR ÜNLÜ

  • ETHEM ÖMEROĞLU: KONYA ŞEHİR HASTANESİ
  • AYŞE NUR UĞUR KILINÇ: KONYA ŞEHİR HASTANESİ
  • Zeynep BAYRAMOĞLU, MD: Dokuz Eylül Üniversitesi Tıp Fakültesi
  • YAŞAR ÜNLÜ: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ
  • Year : 2025
  • Vol : 41
  • Issue : 3
  •  Page : 142-151
ÖZ
Amaç: Bu çalışmada Türk toplumunda Nazal poliplerin (NP) sigara içimi, proliferatif süreçler ve enflamasyon ile ilişkisini histopatolojik ve klinik parametreler doğrultusunda detaylı bir şekilde değerlendirmeyi amaçladık.
Gereçler ve Yöntem: Mart-Ağustos 2021 tarihleri arasında hastanemizde endoskopik sinüs cerrahisi yapılan 36’sı erkek, 19’u kadın toplam 55 nazal polip hastasının patolojik materyalleri incelendi. Hematoksilin ve Eozin (H&E) boyama ile histolojik alt tipler skuamöz metaplazi, epiteliyal hiperplazi gibi histolojik değişikliklerin değerlendirilmesi yapıldı. Ayrıca eozinofil, nötrofil, lenfosit oranları ve yoğunluğu gibi çeşitli inflamatuar durumları değerlendirildi. Bununla birlikte, dokularda sigara içimi ile ilgili gelişebilecek proliferatif değişiklikler immünohistokimya (İHK) yöntemi ile Ki-67 ve p53 boyama değerlendirmeleri yapılarak araştırıldı. Hastane sisteminden elde edilen klinik bilgiler, laboratuvar sonuçları ve Lund-Mackay sınıflaması verileri dahil edildi. Çalışmada R 4.2.2 programı kullanılarak Ki-Kare ve Fisher testleri ile T-testi analizleri gerçekleştirildi.
Bulgular: Hastaların yaş ortalaması 37,22±16.96’dir. Bunlardan 34’ü (61,82%) sigara içmezken, 21’i (38,18%) sigara içmekteydi. Sonuçlarımızda sigara içenlerde ve Lund-Mackay sınıflaması puanı yüksek olanlarda eozinofilik infiltrasyon ile anlamlı bir ilişki gösterdi (p<0.05). Ayrıca, Lund-Mackay puanı yüksek olanlarda eozinofilik ve lenfoplazmositik inflamasyon türleri ile de anlamlı korelasyon saptandı (p<0.05). Nazal poliplerde skuamöz metaplazinin bulunması ile Ki-67 ve p53 immünhistokimyasal boyanma skorları arasında anlamlı ilişki bulunurken, epiteliyal hiperplazi ile bu değerler arasında ilişki bulunmadı.
Sonuç: Çalışmamızda nazal polip hastalarında sigara içimi ile Lund-Mackay sınıflaması sonuçları, inflamasyon tipi ve eozinofilik inflamasyon arasında ilişkiyi gösterdik. Ayrıca, proliferatif belirteçler olan Ki-67 ve p53 bulguları ile metaplazik değişiklikler ve epitel hiperplazi gelişimi arasında korelasyon tespit edildi. Türk toplumunda NP'lerdeki eozinofilik inflamasyon dereceleri Asya ve Avrupa toplumları arasında bir noktada olduğu sonucuna varıldı.
Anahtar Kelimeler: Nazal polip, proliferatif süreç, sigara içimi, Ki-67, p53
Cite this Article As : Omeroglu E, Ugur Kilinc AN, Bayramoglu Z, Unlu Y. The Evaluation of Nasal Polyps in Terms of Smoking, Proliferative Processes, and Inflammation: Cross-Sectional Study. Selcuk Med J 2025;41(3): 142-151

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2025, Vol. 41 (3)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

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