The Eveluation Of Cystic Fibrosis Frequency In Children With Malnutrition And/ Or Recurrent Pulmonary Infection

Cystic fibrosis (CF) which is occurred by mutations in the gene regulation of transmembrane message shows autosomal recessive inheritance. It is also the most common fatal diseases in white race. The frequency of disease is estimated as 1/2500-1/3500 in white race, 1/1700 in African Americans. But the frequency of CF is not known for our countries. In this study, the frequency of disease was tried to find in children with malnutrition and/or recurrent pulmonary infections who admitted to hospital. This prospective study was conducted between February 2007 and January 2010 and children with malnutrition and/or recurrent pulmonary infections were enrolled the study. The diagnosis CF was made by using positive sweat test and appropriate clinical findings and rule out of other diseases which also caused recurrent pulmonary infections or malnutrition. A total of 491 children were enrolled the study. The mean age of children was 26,1±35.01 months with the range of 2-216 months. Of all children, 335 (68.3%) were male and 156 (31.7%) were female. Positive sweat test was found in 35 (7.1 %) children. The frequency of CF was found to be 5.3 % in children with malnutrition and 8.8 % in children with recurrent pulmonary infections. Finally we emphasized one more times that CF should be keep in mind in children with malnutrition and/or recurrent pulmonary infections due to its early diagnosis and prevention of late complications.