The Fetomaternal Toxicity Evaluation of Nitrogen Mustard (HN2) at the Level of Lethal Dose (1-Dso-Lploo) in Rats

Osman Özcan, SELÇUK DUMAN, Kemal Irmak, HÜSEYİN UYSAL, HASAN KOÇ

  • Osman Özcan: Selçuk Üniversitesi GATA
  • SELÇUK DUMAN: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Kemal Irmak: Selçuk Üniversitesi Tıp Fakültesi
  • HÜSEYİN UYSAL: SELÇUK ÜNİVERSİTESİ
  • HASAN KOÇ: SELÇUK ÜNİVERSİTESİ
  • Year : 1993
  • Vol : 9
  • Issue : 2
  •  Page : 197-204
in this study whose object was to invest the ef-fects of nitrogen mustard in the level of LD5o and LDloo on nonmalignant tissues 30 rats were used. The effects of nitrogen mustard which was giyen int-raperitoneally to pregnant rats were investigated with light microscope. In the liver degenerative defects which increased with increasing dose, in the spleen white pulp orga-nization defects, in the kidney focal bleedings and in the peripheric blood smear leucopenie were detected. After procces it was observed that embrios were re-sorbed. It was emphasised that in the obligation of the use of nitrogen mustard in pregnants the toxic ef-fects should be taken care.

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1993, Vol. 9 (2)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :