THE INVESTIGATION OF OLFACTORY FUNCTION RELATED QUALITY OF LIFE AND PSYCHOLOGICAL SYMPTOMS IN PATIENTS WITH TRANSFUSION DEPENDENT BETA THALASSEMIA

Yasin Yılmaz , Doğa Dalay , Zeynep Karakas

  • Yasin Yılmaz: Istanbul University Istanbul Medical Faculty
  • Doğa Dalay: Istanbul University Istanbul Medical Faculty
  • Zeynep Karakas: Istanbul University Istanbul Medical Faculty
  • Year : 2025
  • Vol : 41
  • Issue : 3
  •  Page : 131-135
ABSTRACT
Objective: Transfusion-dependent beta thalassemia (TDBT) patients may be at risk for psychological symptoms due to chronic disease, which can burden their lives. Sense of smell problems may also accompany chronic disease and lead to qualityof life problems. his study examined the relationship between olfactory function, quality of life and psychological symptoms in transfusion-dependent beta-thalassemia patients.
Materials and Methods: Forty-six TDBT patients followed up at the Thalassemia Center of Istanbul Medical Faculty were included in the study. The 12-item selfreported olfactory function and olfactory quality of life assessment questionnaire (ASOF) and the Hospital Anxiety and Depression Scale (HAD) were used to screen olfactory function capacity, olfactory-related quality of life and psychological symptoms. Statistical analysis was performed with SPSS (v23) software.
Results: The mean age of the 46 participants was 32.5±7.3 years. The overall olfactory capacity score was 8.8±1.3, the specific olfactory capacity score was 4.6±0.5 and the odor-related quality of life score was 4.7±0.4. The HAD scale showed that 22% of the patients had anxiety symptoms and 65% had depression symptoms. There was a significant negative correlation between anxiety and depression scores and general olfactory capacity (p=0.02). Patients with depression symptoms and anxiety symptoms showed lower olfactory capacity (p<0.05). Olfactory quality of life was also significantly reduced in patients with depression symptoms (p<0.05). Patients receiving deferasirox (DFX) showed better olfactory capacity (p<0.01).
Conclusion: A significant negative correlation was found between olfactory capacity and anxiety and depression scores. Patients with symptoms of depression showed a decrease in quality of life related to olfactory function. Chelation type seems to be associated with olfactory capacity.
Keywords: Anxiety, beta thalassemia, quality of life, depression, olfactory dysfunction
Cite this Article As : Yilmaz Y, Dalay D, Karakas Z. The Investigation of Olfactory Function Related Quality of Life And Psychological Symptoms In Patients With Transfusion Dependent Beta Thalassemia. Selcuk Med J 2025;41(3): 131-135

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Conflict of interest : The authors declare that they have no conflict of interest.
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
2025, Vol. 41 (3)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :

References

  1. 1. 1. Origa R. Genetic basis, pathophysiology and diagnosis of thalassemias. In: Cappellini MD, Farmakis D, Porter J, Taher A, (eds). Guidelines for the management of transfusion dependent thalassemia (TDT), 4th edn. Nicosia:Thalassaemia International Federation (TIF) Publication, 2021; pp 20–36
  2. 2. Nemtsas P, Arnaoutoglou M, Perifanis V, et al. Neurological complications of beta-thalassemia. Ann Hematol. 2015;94(8):1261-65 . doi: 10.1007/s00277-015-2378-z.
  3. 3. Khoury B, Musallam KM, Abi-Habib R, et al. Prevalence of depression and anxiety in adult patients with β-thalassemia major and intermedia. Int J Psychiatry Med. 2012;44(4):291-03 . doi: 10.2190/PM.44.4.a.
  4. 4. Töret E, Karadaş NÖ, Gökçe NÖ, et al. Quality of Life and Depression in Turkish Patients with β-Thalassemia Major: A Cross-Sectional Study. Hemoglobin. 2018;42(5-6):326-29 . doi: 10.1080/03630269.2018.1551231.
  5. 5. Borgna-Pignatti C. The life of patients with thalassemia major. Haematologica 2010;95(3):345-48. doi: 10.3324/haematol.2009.017228.
  6. 6. Yilmaz Y, Karakas Z, Uzun B, et al. Olfactory dysfunction and quality of life in patients with transfusion-dependent thalassemia. Eur Arch Otorhinolaryngol. 2017 ;274(9):3417-21. doi: 10.3324/haematol.2009.017228.
  7. 7. Doty RL. Olfactory dysfunction and its measurement in the clinic and workplace. Int Arch Occup Environ Health 2006;79(4) : 268–82. doi: 10.1007/s00420-005-0055-6.
  8. 8. Liu DT, Prem B, Sharma G, et al. Depression Symptoms and Olfactory-related Quality of Life. Laryngoscope. 2022;132(9):1829-34. doi: 10.1002/lary.30122.
  9. 9. Amid A, Saliba AN, Taher AT, et al. Thalassaemia in children: from quality of care to quality of life.Arch Dis Child. 2015;100(11):1051-57 . doi: 10.1136/archdischild-2014-308112.
  10. 10. Pusswald G, Auff E, Lehrner J. Development of a Brief Self-Report Inventory to Measure Olfactory Dysfunction and Quality of Life in Patients with Problems with the Sense of Smell. Chem. Percept. 2012; 5 (1):292-99. doi:10.1007/s12078-012-9127-7
  11. 11. Saatçi Ö, Arıcı Düz Ö, Altundağ A. Reliability and Validity of the Turkish Version of the Questionnaire for the Assessment of Self- Reported Olfactory Functioning and Olfaction-Related Quality of Life. J Acad Res Med 2020;10(3):277-82. doi:10.4274/jarem.galenos.2020.3579
  12. 12. Zigmund AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983;67(6) :361-70. doi: 10.1111/j.1600-0447.1983.tb09716.x.
  13. 13. Aydemir Ö, Güvenir T, Küey L, et al. Validity and reliability of Turkish version of Hospital Anxiety and Depression Scale. Turkish Journal of Psychiatry 1997;8(4) :280-87. Doi eklenmeli
  14. 14. Choudhry VP. Quality of Life in Thalassemia Major. Indian J Pediatr. 2018;85(11):957-58. doi: 10.1007/s12098-018-2792-z.
  15. 15. Chordiya K, Katewa V, Sharma P, et al. Quality of Life (QoL) and the Factors Affecting it in Transfusion-dependent Thalassemic Children. Indian J Pediatr. 2018;85(11):978-83. doi: 10.1007/s12098-018-2697-x.
  16. 16. Nashwan AJ, Yassin MA, Babu GDJ, et al. Quality of life among adolescents aged 14 to 18 years with Beta-Thalassemia Major (TM) in Qatar. Acta Biomed. 2018;89(2-S):16-26. doi: 10.23750/abm.v89i2-S.7083.
  17. 17. Etemad K, Mohseni P, Aghighi M, et al. Quality of Life and Related Factors in β-Thalassemia Patients. Hemoglobin. 2021;45(4):245-49. doi: 10.1080/03630269.2021.1965617.
  18. 18. Tuysuz G, Tayfun F. Health-related Quality of Life and its Predictors Among Transfusion-dependent Thalassemia Patients. J Pediatr Hematol Oncol. 2017;39(5):332-36. doi: 10.1097/MPH.0000000000000790.
  19. 19. Zolaly MA, Zolaly FM, Al Belowi L, et al. Depression, Anxiety, and Stress Symptoms in Patients with Beta Thalassemia Major in Almadinah Almunawwarah, Saudi Arabia. Cureus. 2020;12(11):e11367. doi: 10.7759/cureus.11367.
  20. 20. Adib-Hajbaghery M, Ahmadi M, Poormansouri S. Health Related Quality of Life, Depression, Anxiety and Stress in Patients with Beta-Thalassemia Major. Iran J Ped Hematol Oncol. 2015;5(4):193-05. Doi eklenmeli
  21. 21. Maheri A, Sadeghi R, Shojaeizadeh D, et al. Depression, Anxiety, and Perceived Social Support among Adults with Beta-Thalassemia Major: Cross-Sectional Study. Korean J Fam Med. 2018;39(2):101-07. doi: 10.4082/kjfm.2018.39.2.101
  22. 22. Yengil E, Acipayam C, Kokacya MH, et al. Anxiety, depression and quality of life in patients with beta thalassemia major and their caregivers. Int J Clin Exp Med. 2014;7(8):2165-72. Doi eklenmeli
  23. 23. Mohamadian F, Bagheri M, Hashemi MS, et al. The Effects of Cognitive Behavioral Therapy on Depression and Anxiety among Patients with Thalassemia: a Randomized Controlled Trial. J Caring Sci. 2018;7(4):219-24. doi: 10.15171/jcs.2018.033.
  24. 24. Kohli P, Soler ZM, Nguyen SA, et al. The association between olfaction and depression: a systematic review. Chem Senses. 2016;41(6):479-86. doi: 10.1093/chemse/bjw061.
  25. 25. Taalman H, Wallace C, Milev R. Olfactory functioning and depression: a systematic review. Front Psych. 2017;8:190. doi: 10.3389/fpsyt.2017.00190.