The Nephrotoxie Effect of Cyclosporin

Nahit Ökesli, Yüksel Tatkan, ADNAN KAYNAK, MUSTAFA ŞAHİN, YÜKSEL ARIKAN

  • Nahit Ökesli: Selçuk Üniversitesi Tıp Fakültesi
  • Yüksel Tatkan: Selçuk Üniversitesi Tıp Fakültesi
  • ADNAN KAYNAK: SELÇUK ÜNİVERSİTESİ
  • MUSTAFA ŞAHİN: SELÇUK ÜNİVERSİTESİ
  • YÜKSEL ARIKAN: AFYON KOCATEPE ÜNİVERSİTESİ
  • Year : 1990
  • Vol : 6
  • Issue : 3
  •  Page : 252-257
A This study was carried out to shof the nephrotoxicıty due to renal perfwion with Cyclosporin A biochemically and histopathologically. Il'e have performed renal arterial and venous catheterisation in 10 dogs and persufsed 50 mg Cy-elosporin A in 200 ınl of lactated Ringer's solution at + 4'C ander 100 em water pressure through re-nal arter. Serum creatinin and BUN were increased in postoperative controls. The hıstopathologic fea-tures of the nephrotoxicity was determined. Nephrotoxicity developed by this procedure can be reduced down by using smaller dosage. Ilowewer, the immünosuppresive ejfect of reduced dosage should be studied.

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1990, Vol. 6 (3)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :