The protective action of ethylenediamine tet-raacetic acid disodium salt against ouabain toxicity in mice.

İlhan Gültekin, Şerare Atçı, Yusuf Karataş, ERGİN ŞİNGİRİK, Firuz Baysal

  • İlhan Gültekin: Çukurova Üniversitesi Tıp Fakültesi
  • Şerare Atçı: Çukurova Üniversitesi Tıp Fakültesi
  • Yusuf Karataş: Çukurova Üniversitesi Tıp Fakültesi
  • ERGİN ŞİNGİRİK: ÇUKUROVE ÜNİV
  • Firuz Baysal: Çukurova Üniversitesi Tıp Fakültesi
  • Year : 1997
  • Vol : 13
  • Issue : 1
  •  Page : 8-12
In this study, the protective action of the •he-lating agent ethylenediamine tetraac:etic acid di-sodium (Na2 EDTA) against ouabain intoxication in healthy mice was investigated_ Although Na, EDTA, at the concentrations tested (10. 20. 40 and 80 mgl kg) had no effects alone. it abolished the toxic elfect induced hy 5 mglkg ouabain at the doges of 40 ad 80 mgikg. The toxic elfect of 15mgikg ouabain was also significantly inhihited hy the highest dose of Nal EDTA (80 mglkg). These results suggest that Na2 EDTA has protective action against ouabain to-xicitiy due ta chelation of calcium.

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1997, Vol. 13 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :