THE RELATIONSHIP BETWEEN NEUTROPHIL ELASTASIE, IL-1Β, IL-8 AND DESMOSIN LEVELS IN SPUTUM AND BLOOD WITH SPUTUM CULTURE RESULTS IN PATIENTS WITH BRONCHIECTASIS

Abstract
Aim: In our study, we aimed to investigate the diagnostic value of NE in blood and sputum, blood IL-8, IL-1β and desmosine levels and their relationship with symptoms, frequency of exacerbation, etiology, prevalence of radiological involvement, types of bronchiectasis, as well as sputum cell counts and cultures.
Patients and Methods: The study included 46 patients with bronchiectasis aged between 18-90 years, who applied to the Chest Diseases Polyclinic between November 2020 and March 2021 and were followed up by our clinic, and a control group of 45 people.
Results: At blood, NE, IL-1β, desmosine were statistically significantly higher in the patient group (p<0.001). ROC analysis was performed for the diagnostic value of biomarkers. When the cut-off value for blood NE was 12.70 ng/mL, the sensitivity was 71.7%, the specificity was 77.8%, for IL 1β the cut-off value was 2.935 pg/mL, the sensitivity was 73.9%, the specificity was 71.1%, for desmosine, the cut-off value was 0.505 ng/mL, the sensitivity was 67.4% and the specificity was 62.2%.
Conclusion: In our study, it was found that NE, IL-1β and desmosine in blood and NE in sputum in patients with bronchiectasis are important inflammatory markers, have significant diagnostic value, and may be an important component of follow-up parameters, since these parameters are significantly correlated with the frequency of exacerbations.
Keywords: Bronchiectasis, neutrophil elastase, desmosine, IL-8, IL-1β, sputum culture