The Relaxant Effects of Verapamil, Nifedipine and Nitrendipine in Isolated Rat Gastro-Oesophageal Sphincter

Ekrem Çiçek, AHMET KAYA, Laika Karabulut, ERGİN ŞİNGİRİK, Necdet Doğan

  • Ekrem Çiçek: Süleyman Demirel Üniversitesi Tıp Fakültesi
  • AHMET KAYA: NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Laika Karabulut: Selçuk Üniversitesi Tıp Fakültesi
  • ERGİN ŞİNGİRİK: ÇUKUROVE ÜNİV
  • Necdet Doğan: Selçuk Üniversitesi Meram Tıp Fakültesi
  • Year : 1989
  • Vol : 5
  • Issue : 1
  •  Page : 9-14
In this in vitro study performed in the rat gastro-esophageal sphincter, the relaxing effects of verapamil, nifedipine and nitrendipine, which are Ca2 + channel blockers, on contractions due to carbachol were investigated. When the% relaxations obtained with the said antagonists were compared, it was seen that verapamil and nitrendipine relaxed at the same rate, whereas the relaxation achieved with nitrendipine was lower than the other two drugs.

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Conflict of interest : Yok
This article is published under the CC BY-NC 4.0 license.
Selcuk Medical Journal
1989, Vol. 5 (1)
ISSN: 1017-6616
E-ISSN: 2149-8059
Received : , Accepted : , Published Online :