Clinical, Laboratory And Epidemiological Characteristics Of Familial
Mediterranean Fever In Childhood And The Relationship Between
These Features With Genetic Mutations
HARUN PERU, BÜLENT ATAŞ, ADNAN KARAİBRAHİMOĞLU
- Year : 2016
- Vol : 32
- Issue : 1
- Page :
1-7
Familial Mediterranean Fever (FMF) is characterized by attacks
and inflammation of serous membranes. After discovery of MEVF
mutations, several studies have been carried out about the effect
of genotype to phenotype, a number of them showed relationship
between genotype and phenotype, but some of them not. The aim
of our study was to investigate the relationship between genotype
and clinical features in children with FMF. This study was performed
with 131 patients who have FMF diagnosis. The demographic data,
clinical findings, mutations were investigated retrospectively. 52.7%
of our patients were boys, 47.3% were girls. Distribution of the age
of diagnosed was different from age of onset of symptoms (p=0.00).
The most frequent symptom was abdominal pain (94.7%) and it is
followed by fever (91.6%), arthralgia (65.6%) and chest pain (27.5%).
Infection, stress, menstruation and physical training triggered the
attack in some patients. Respectively, the most common mutations
were M694V (50.4%), M680I (26.7%) and 148Q (11.5%). No mutation
was detected in 14.5% of our patients. Nausea and vomiting were
less in M694V homozygous patients, and arthralgia was higher in
E148Q heterozygous patients (p<0.05). We had 3 patients with
colchicine-resistant who were siblings. In our study, a significant
relationship between phenotype and genotype was not observed. It
is difficult to recognize the disease in infancy period, FMF should be
considered in patients with frequently admitted to hospital in order to
avoid complications.
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Description :
None of the authors, any product mentioned in this article,
does not have a material interest in the device or drug. Research,
not supported by any external organization.
grant full access to the primary data and, if requested by the magazine
they agree to allow the examination of data.
Clinical, Laboratory And Epidemiological Characteristics Of Familial
Mediterranean Fever In Childhood And The Relationship Between
These Features With Genetic Mutations
2016,
Vol.
32
(1)
Received : 14.05.2015,
Accepted : 14.05.2015,
Published Online : 13.08.2018
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;