Comparison Of The Effects Of Mannitol Or Hypertonic Saline Solutions In Head Trauma Model

FERİDE AYGIN, ALPER YOSUNKAYA, AYBARS TAVLAN

  • Year : 2011
  • Vol : 27
  • Issue : 1
  •  Page : 1-5
We aimed to compare the effects of 20 % mannitol, 3 % or 7 % hypertonic saline on hemodynamic parameters, intracranial pressure and electroencephalography in experimental head trauma. Bilateral craniotomy were carried out in the parietal region and standart head trauma was applied for all rabbits. The rabbits were randomly divided into four groups. In group I rabbits were only observed. In group II: 20 % mannitol, in group III: 3 % hypertonic saline and in group IV: 7 % hypertonic saline was administered intravenously to achieve similar osmolar load. Electroencephalography, mean arterial pressure, heart rate, intracranial pressure were recorded before trauma and 5 and 60 minutes after trauma. Increased intracranial pressure was significantly decreased by mannitol, 3 % and 7 % hypertonic saline solutions at the end of study (p0.05). The mean arterial pressure and heart rates increased after trauma in all groups (p
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Comparison Of The Effects Of Mannitol Or Hypertonic Saline Solutions In Head Trauma Model
, Vol. 27 (1)
Received : 03.05.2010, Accepted : 03.05.2010, Published Online : 13.08.2018
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ISSN:1017-6616;
E-ISSN:2149-8059;