Comperision of Antibiotic+Antiinflamatuar and Antibiotic+Alfa Blocker Therapy Effectivity Comparison of İnflamatuar Chronic Pelvic Pain Syndrome Treatments a Placebo Controlled Study

Aim: In our study, we evaluated the effect of antibiotics together with alpha-blocker and anti-inflammatory drugs; and we compared the effect of these treatments with placebo in patients with inflammatory chronic pelvic pain syndrome. Material and Method: Seventy-six patients with diagnosed NIH category 3A chronic prostatitis were included in this study. Placebo group included 19 patients (group 1), antibiotic + anti-inflammatory drug group included 29 patients (Group 2), while antibiotic + alpha-blocker group composed of 28 patients (Group 3). Before and after treatments all patients were evaluated separately according to national institutes of health-chronic prostatitis symptom index (NIH- CPSI) total score and pain, voiding and life quality scores. In addition; residual urine, maximum urinary flow (Q max) and prostate specific antigen (PSA) values were evaluated. All parameters of the 3 groups were evaluated by t-test before and after treatments. The values of the 3 groups after treatment were compared together by Mann Whitney-U test. Result: Patients mean age was 33.31(19-51). When we compared the pre-treatment and post treatment values of the placebo group, the pain, voiding, total NIH-CPSI score; there was a significant improvement while there were no statistically difference in other parameters. In group 2, there were statistically significant change in all parameters except Qmax, residual urine. In group 3, all parameters showed significant improvement. In comparison of the 3 groups, we found that the third group showed a more significant change than the other two groups. The patients tolerated the treatment well and there were no serious side effects. Conclusion: In our study we found that combination of antibiotics, alpha-blockers, and antiinflamatories are effective in treatment of category 3A chronic prostatitis.