Correlations Of Vitamin D Level With Hormonal And Biochemical Parameters In Polycystic Ovary Syndrome

SUNA KABİL KUCUR, İLAY GÖZÜKARA, HAVVA YILMAZ, AYŞENUR AKSOY, EDA ÜLKÜ ULUDAĞ, HÜLYA UZKESER, YASEMİN KAYA, ESRA ADEMOĞLU, AYŞE ÇARLIOĞLU, ŞENAY ARIKAN

  • Year : 2014
  • Vol : 30
  • Issue : 4
  •  Page : 155-158
To investigate the level of 25(OH)D and association between 25(OH)D level and hormonal-biochemical parameters in Polycystic ovary syndrome (PCOS). Thirty three patients diagnosed with PCOS and 42 age- body mass index (BMI) matched control group admitted to Bolge Training and Research Hospital from May to October were included in the study. Serum total testosterone (TT), free testosterone (fT), 25(OH)D, dihydroepiandrostenodione sulphate, LH, FSH, thyroid stimulating hormone (TSH), cortisol, 17αOH-progesterone, fasting glucose, insulin levels were evaluated after 12 hour fasting. HOMA-IR (fasting glucose level x fasting insülin / 405) was calculated. Serum 17αOH progesterone and 25(OH)D levels were significantly lower in PCOS group (p<0.01). Serum LH, LH/ FSH TT, FT, insulin, ACTH, and DHEAS levels were significantly higher in PCOS group (p<0.01). There was statistically significant negative correlation of 25(OH)D levels with PCOS, LH/FSH, TT, fT, DHEAS ve FGS. There was no statistically significant correlation between 25(OH)D levels and age, body mass index and insulin resistance. The results of this study indicated that vitamin D deficiency is highly prevalent among women with PCOS independent of body mass index. We also demonstrated that vitamin D deficiency was correlated with hyperandrogenism in PCOS women. Low serum 25(OH)D levels might exacerbate PCOS symptoms. Large intervention trials are needed to evaluate the effect of vitamin D supplementation on hormonal and clinical parameters in PCOS women.
Cite this Article As : Kucur SK,Gözükara İ,Yılmaz H,Aksoy A,Uludağ EÜ,Uzkeser H,Kaya Y,Ademoğlu E,Çarlıoğlu A,Arıkan Ş.Polikistik Over Sendromunda D Vitamini Seviyesinin Hormonal ve Biyokimyasal Parametrelerle İlişkisi.Selcuk Med J 2014;30(4): 155-158

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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Correlations Of Vitamin D Level With Hormonal And Biochemical Parameters In Polycystic Ovary Syndrome
, Vol. 30 (4)
Received : 23.02.2014, Accepted : 23.02.2014, Published Online : 13.08.2018
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;