Does Experimental Morphine Addiction in Rats Change Physiological and Histological Characteristics of the Heart?

HANDE ÇAĞLIYAN, Z IŞIK SOLAK GÖRMÜŞ, HATİCE SOLAK, RAVİYE ÖZEN KOCA, BURCU GÜLTEKİN

  • Year : 2022
  • Vol : 38
  • Issue : 3
  •  Page : 128-135

Aim: Morphine is one of the most preferred opioids in treatment of chronic pain. Recurrent use can
cause addiction. There is no consensus on cardiovascular system treatment/side effects of opioids. In
order to investigate effects of opioid addiction on heart, myocardial contractility/histological changes were
investigated in rats via experimental morphine addiction/withdr awal.
Materials and Methods: 32 adult male Wistar albino rats used for study, which was officially completed
on 28-05-2021, were divided into Control(C), Morphine(M), Morphine+Naloxone(MN) groups randomly. In
GroupC 10mg/kg 0.9% NaCl solution, in GroupM-MN 10mg/kg morphine were administered subcutaneously
for 7 days. After the last administration of morphine, 3mg/kg NaCl was given to GroupC-M, 3mg/kg naloxone
was given to GroupMN intraperitoneally. Signs of morphine withdrawal were observed for 30 minutes
and scored. 3-4mm strips of atria were hung in isolated organ bath chambers. Tension was adjusted to
2g. Adrenaline-induced contractions (0.001M) were observed. Changes in tension were recorded. SAS
University Edition 9.4 program was used for statistical analysi s.
Results: Morphine withdrawal behaviours were observed in GroupMN. There was no statistically
significant difference between atrial contractility tension values of GroupC-M-MN(p>0.05). Pre-adrenaline
tension values were higher in GroupM-MN than in GroupC. But the greatest contraction increase between
15minutes before/after adrenaline-induced data was in GroupC.
Conclusion: Morphine addiction/withdrawal didn’t cause inotropic/chronotropic changes. No histological
differences were observed in mast cells. These results may constitute a positive resource for the heart for
systems analysis in morphine addicts.

Cite this Article As : Caglayan H, Solak Gormus ZI, Solak H, Ozen Koca R, Gultekin B. Does Experimental Morphine Addiction in Rats Change Physiological and Histological Characteristics of the Heart? Selcuk Med J 2022;38(3): 128-135

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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Does Experimental Morphine Addiction in Rats Change Physiological and Histological Characteristics of the Heart?
, Vol. 38 (3)
Received : 17.08.2022, Accepted : 17.08.2022, Published Online : 08.09.2022
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;