EVALUATION OF THE RELATIONSHIP BETWEEN METABOLIC PARAMETERS, AND VITAMIN D LEVELS IN CHILDREN WITH INSULIN-DEPENDENT DIABETES MELLITUS

ABSTRACT
Objective: Vitamin D play an important role in hyperlipidemia, cardiovascular disease risk, and glucose/insulin metabolism. The aim of this study is; To investigate the relationship between serum vitamin D levels and metabolic profiles of children with 
type 1 diabetes mellitus ( T1DM), atherogenic index, and cardiovascular disease risk.
Materials and Methods: Anthropometric and clinical measurements, biochemical parameters, atherogenic plasma index (AIP) values and serum vitamin D levels were evaluated.
Results: The study included 307 diabetic patients, 152 (49.5%) females and 155 (50.5%) males, with a mean age of 11.5±3.87. Vitamin D deficiency (77.5%; (n=193)) was detected in the majority of our patients. The mean daily insulin dose of patients with low vitamin D levels was 0.91±0.31 U/kg/day; mean hemoglobin A1C (HbA1C) level 11.77%; in those with normal vitamin D levels, the mean insulin dose is 0.94±0.28 U/kg/day; the HbA1C level was found to be 12.19% (p>0.05). While the mean atherogenic plasma index level in females was 0.28±0.33; it was 0.25±0.31 in males (p>0.05). While the mean atherogenic plasma index of cases with vitamin D deficiency was 0.29±0.31, the mean of atherogenic plasma index in those without vitamin D deficiency was found to be 0.13±0.28 (p<0.001).
Conclusion: Atherogenic plasma index was higher in patients with vitamin D deficiency. According to the data obtained as a result of the study; low vitamin D and high atherogenic plasma index levels are important predictors of cardiovascular complications. It is thought that close monitoring of these parameters will be a guide in preventing long-term morbidity in children with type 1 diabetes mellitus.
Keywords: Type 1 Diabetes Mellitus, Atherogenic Index, Vitamin D