Five-Year Survival Outcomes Of Breast Cancer And Prognostic
Factors. A Single Institution Experience
GÜL KANYILMAZ, MERYEM AKTAN, BERRİN BENLİ YAVUZ, MEHMET KOÇ
- Year : 2017
- Vol : 33
- Issue : 1
- Page :
5-9
To evaluate the five year survival outcomes of breast cancer
patients treated at our department and to assess the prognostic
factors that affect survival parameters. All patients underwent our
department’s routine procedure for breast cancer. All patients received
RT to the breast or chest wall using 3D conformal technique with 2 Gy
fraction doses, five days a week with two opposite tangential fields.
If necessary, ipsilateral supraclavicular fossa field was added to the
treatment field. Anthracycline-based chemotherapy was primarily
used, patients with estrogen receptor- positive disease received
hormonal therapy and patients with Her-2 receptor-positive disease
received trastuzumab. The primary end points of this study were
to evaluate the overall survival (OS) and the disease-free survival
(DFS) of the patients. The secondary end points of this study were
to assess the prognostic factors that affect the survival outcomes.
Statistical analysis were carried out using SPSS Statistic program
version 13. Between 11.02.2010 and 01.05.2016, 559 patients with
breast cancer who had been irradiated postoperatively were included
in this retrospective study. 2 and 5 year OS rates were 97% and 84%;
2 and 5 year DFS rates were 97% and 71%, respectively. According to
multivariate analysis, ≥70 year, to have triple (-) hormonal status, to
have T3-4 disease, to have N2-3 nodal stage and to have locoregional
recurrence or distant metastasis were the independent prognostic
factors that affect OS. Also, to have N2-3 nodal stage and to have
triple (-) hormonal status were independent prognostic factors that
affect DFS. Breast cancer is the most common cancer among women.
Its incidence has been increasing but mortality has been decreasing
in the last 10-15 years. In the light of current treatment modalities,
to know the prognostic factors that affect survival outcomes is very
important for both choosing the most appropriate treatment modality
and the prediciton of treatment response.
Cite this Article As :
Kanyılmaz G, Aktan M, Yavuz BB, Koç M. Meme kanserinde 5 yıllık tedavi sonuçlarımız ve prognostik faktörler. Selcuk Med J 2017;33(1): 5-9
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Description :
None of the authors, any product mentioned in this article,
does not have a material interest in the device or drug. Research,
not supported by any external organization.
grant full access to the primary data and, if requested by the magazine
they agree to allow the examination of data.
Five-Year Survival Outcomes Of Breast Cancer And Prognostic
Factors. A Single Institution Experience
2017,
Vol.
33
(1)
Received : 02.12.2016,
Accepted : 02.12.2016,
Published Online : 13.08.2018
Selçuk Tıp Dergisi
ISSN:1017-6616;
E-ISSN:2149-8059;