Frequency of consanguinity, karyotype distribution and sex ratio of cases with trisomy 21

Sennur Demirel, AYNUR ACAR, TÜLİN ÇORA, HATİCE GÜL DURSUN, AYŞEGÜL ZAMANİ, HASAN ACAR

  • Year : 1998
  • Vol : 14
  • Issue : 4
  •  Page : 165-168
This study included 126 Down syndrome cases (81 males and 45 females) who had regular trisomy 21 in 120 cases, chromosome 21q trisomy in 5 and a mosaic karyotype in one case. The ratio of males to females was found to be 2:1 in regular trisomy 21 and 1:4 in chromosome 21q trisomy. The study implicated that trans-locations that were found were mostly matemal in origin. it is alsa noteworthy that the frequency of consanguinity among the parents having children with Down syndrome (21.6%) was not different from the population fre-quency in Konya (23.2%). Moreover, the mean age of ~her having children with Down syndrome was de-termined to be 30.7
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Frequency of consanguinity, karyotype distribution and sex ratio of cases with trisomy 21
, Vol. 14 (4)
Received : 10.10.1998, Accepted : 10.10.1998, Published Online : 06.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;