Investigation Of Effect Of Acetylsalicylic Acid On Serum Lipids

The aim of the study was to investigate the effect of 100 and 150 mg/day acetylsalicylic acid (ASA, aspirin) treatment on blood lipids. The study group consisted of 30 healthy volunteers. Of the volunteers, 17 (7F, 10M) received ASA as 100 mg (Group I) and 13 (5F, 8M) received ASA as 150 mg (Group II) daily for a period of two months. Fasting blood samples of the subjects were drawn before and 1 and 2 months after ASA treatment. Serum total cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride levels of the subjects were measured by routine methods. Low-density lipoprotein (LDL) cholesterol levels were calculated by Friedwald formula. Althought total cholesterol, LDL cholesterol and triglyceride levels were slightly decreased and HDL cholesterol levels were slightly increased 2 months after ASA treatment in both groups, the differences between lipid levels were not statistically significant. In conclusion, ASA treatment at 100 and 150 mg daily for a period of 2 months has no significant effect on blood lipid levels and further investigations about ASA treatment for longer time and at higher doses might be useful.