Matrix Metalloproteinase And Tissue Inhibitors Of Matrix Metalloproteinase During Pregnancy

HAKAN ÖNER, JALE ÖNER

  • Year : 2013
  • Vol : 29
  • Issue : 2
  •  Page : 95-99
During pregnancy, some structural changes take place in the uterus endometrium These structural changes have been characterized by remodeling and distruption of the extracellular matrix (ECM). Remodelling and distruption of uterine endometrium have importance for a successful implantation and placentation. MMPs are a group of zinc-dependent endopeptidases that degrade a variety of components of ECM and basal membrane. The activity of MMPs occurs as a result of balance between activated MMPs and their inhibitors (TIMPs). Earlier experimental studies indicated that MMPs and TIMPs have essential role in ESM destruction and remodeling while blastocyt implantation and trophoblast invasion during early pregnancy. Therefore, MMPs and TIMPs are crucial to the beginning and continuation of pregnancy.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Matrix Metalloproteinase And Tissue Inhibitors Of Matrix Metalloproteinase During Pregnancy
, Vol. 29 (2)
Received : 04.10.2011, Accepted : 04.10.2011, Published Online : 13.08.2018
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ISSN:1017-6616;
E-ISSN:2149-8059;