Pharmacogenetic Dependent Interindividual Pharmacokinetic
Variations
MEVRA AL, MEHMET KILIÇ, AYŞE SAİDE ŞAHİN, BURAK CEM SONER
- Year : 2017
- Vol : 33
- Issue : 4
- Page :
82-90
Pharmacogenetics deals with genetic variations and individual
response differences of drugs. The discovery of enzymes responsible
for drug metabolism and the research to DNA sequences encoding
these enzymes enable the creation of individual treatment strategies.
Cytochrome 2B6, cytochrome 2C9, cytochrome C19, cytochrome
2D6, cytochrome 3A4, N-acetyltransferase, dihydropyrimidine
dehydrogenase, thiopurine methyltransferase, UDP-glucuronyl
transferase and catechol-O-methyltransferase enzymes are
mainlyresponsible from drug metabolism and polymorphisms in
enzyme activities affect the pharmacokinetic properties of the drug
which leads to differences in drug response between individuals.
First examples that form of the basis of pharmacogenetic studies
are N-acetyltransferase and cytochrome 2D6 polymorphisms.
Consideration of enzyme polymorphisms that may result with
pharmacokinetic differences during drug choice is important to
increase the success of treatment and to prevent adverse/toxic
reaction risk. The studies about pharmacogenetics, which was studied
about 50 years ago, has become more important nowadays with the
development of gene technology. Individual drug choice will be an
important parameter by further development of pharmacogenetics
in the second 50 years through pharmacogenetic studies that is
accelerated due to technological developments.
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Description :
None of the authors, any product mentioned in this article,
does not have a material interest in the device or drug. Research,
not supported by any external organization.
grant full access to the primary data and, if requested by the magazine
they agree to allow the examination of data.
Pharmacogenetic Dependent Interindividual Pharmacokinetic
Variations
2017,
Vol.
33
(4)
Received : 30.01.2017,
Accepted : 30.01.2017,
Published Online : 13.08.2018
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ISSN:1017-6616;
E-ISSN:2149-8059;