PREDICTIVE VALUE OF CRP-ALBUMIN AND NEUTROPHIL-LYMPHOCYTE RATIO IN PRETERM PREMATURE RUPTURE OF MEMBRANES

ABSTRACT
Objective: This study aimed to evaluate the relationship between C-reactive protein to albumin ratio (CAR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and preterm premature rupture of membranes (PPROM).
Materials and Methods: This prospective study included 143 pregnant women diagnosed with PPROM between 24 and 37 weeks of gestation who presented with leakage of fluid to the Obstetrics and Gynecology Clinic of Necmettin Erbakan University Meram Faculty of Medicine between January 2021 and July 2021. The control group consisted of 108 pregnant women with spontaneous preterm birth without PPROM. Demographic data and complete blood count results were recorded and compared.
Results: There were no statistically significant differences between the groups regarding age, gravidity, parity, and gestational age (p=0.881, p=0.888, p=0.912, p=0.916, respectively). CAR and NLR were significantly higher in the PPROM group compared to the control group (p<0.001 for both ratios). The ability of CAR to diagnose PPROM, evaluated using ROC curve analysis, yielded an AUC of 0.734 (p<0.001). The cut-off value for CAR was 0.1433 with 64.81% sensitivity and 73.97% specificity. The ability of NLR to diagnose PPROM, evaluated using ROC curve analysis, yielded an AUC of 0.650 (p<0.001). The cut-off value for NLR was 5.3937 with 49.59% sensitivity and 87.67% specificity. There was no significant difference in PLR between the groups (p=0.121).
Conclusion: CAR and NLR may be cost-effective, easy-to-use, and practical markers for the early diagnosis of PPROM, which could contribute to improved maternal and neonatal well-being.
Keywords: Albumin, CRP/Albumin Ratio, Preterm Premature Rupture of Membranes, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio