Proliferating celi nuclear antigen (PCNA) in thyroid tumors

NEZAHAT YILDIRIM, İbrahim H. Özercan

  • Year : 2001
  • Vol : 17
  • Issue : 2
  •  Page : 87-90
We have studied on 47 thyroidectomy material that vvere came to Fırat University Medical Faculty Department of Pathology for the determination of proliferative activity. PCNA method vvere applied, normal thyroid(9), adenomatous goiterfl 1), follicular adenoma(7), papillary carcinoma(l6), follicular carcinoma(2) and anaplastic carcinoma(2). Ali cases paraffin sections stained PCNA/cydin monoclonal antibody. Positive painted nuclei vvas evaluated and PCNA indices vvere calculated as percentage. PCNA indices vvere evaluated normal thyroid %0.5, adenomatous goiter %2.1, follicular adenoma %2.6, papillary carcinoma %6.2, follicular carcinoma %15.7 and anaplastic carcinoma %32.2. As a conclution, thyroid carcinomas shovved significantly increased numbers of PCNA positive cells when compared vvith benign thyroid tumors.
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Description : None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Proliferating celi nuclear antigen (PCNA) in thyroid tumors
, Vol. 17 (2)
Received : 24.01.2001, Accepted : 24.01.2001, Published Online : 02.10.2020
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ISSN:1017-6616;
E-ISSN:2149-8059;